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Review Papers | Anaesthesiology | India | Volume 11 Issue 11, November 2022

Comparison of Gabapentin and Pregabalin in Attenuating the Stress Response to Laryngoscopy and Intubation

Dr Chethanananda T. N | Dr Muhammad Raoof VK | Dr. Srudhi Estherin Koshy ^[2]

Abstract: Background: The airway instrumentation of direct laryngoscopy and tracheal intubation are powerful noxious stimuli that should be attenuated by appropriate premedication, smooth induction and rapid intubation. This study compared the efficacy of oral Gabapentin and oral pregabalin to attenuate the stress response of laryngoscopy and endotracheal intubation. Methods: A total of 70 normotensive adult consented patients aged 20?50 years, ASA grade I and II of both gender were randomized into two treatment groups of 35 patients each. Group A received oral Gabapentin 600 mg, Group B oral pregabalin 150 mg, 1 h prior to induction. Anaesthetic technique was standardized and all groups were assessed for pre?operative sedation, haemodynamic changes after the premedication, before and after induction, after laryngoscopy and intubation, along with intraoperative haemodynamic stability and post?operative side?effects. Results: In both the groups, all the haemodynamic parameters were maintained within (20% of baseline values) throughout the study period. There was no statistically significant difference in MAP between two groups (P > 0.05). Conclusion: Oral Gabapentin and pregabalin can attenuate the haemodynamic stress responses of laryngoscopy and endotracheal intubation without significant differences in MAP between two groups.

Keywords: Haemodynamic pressor response, intubation, laryngoscopy, gabapentin pregabalin

Edition: Volume 11 Issue 11, November 2022,

Pages: 1205 - 1209

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