International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064

Downloads: 6 | Weekly Hits: ⮙3 | Monthly Hits: ⮙6

Research Paper | Orthopaedic Surgery | India | Volume 11 Issue 11, November 2022

Intra Articular PRP Injection for Stage 1&2 Osteoarthritis of Knee

Dr Vaibhav Naidu Majji | Dr V Nageswara Rao | Dr Vijay Krishna Adusumalli

Abstract: Background: Platelet rich plasma (PRP) is defined as a volume of the plasma fraction of Autologous blood having a platelet concentration above baseline. Platelets contain bioactive proteins responsible for attracting macrophages, mesenchymal stem cells, and osteoblasts which not only promote removal of necrotic tissue, but also enhance tissue regeneration. Osteoarthritis of knee is a chronic and progressive joint disease that leads to articular cartilage damage, bone deformation, osteophyte formation and synovial inflammation. Treatment options for knee OA vary from simple analgesia in mild cases to knee replacement for advanced disease. Knee pain and early degeneration due to early stages of OA can be targeted with regenerative techniques such as use of intra articular platelet rich plasma was proposed. In this review, we present a comprehensive overview of the efficacy of Intra articular PRP for stage 1&2 OA of knee. Materials and Methods: A Prospective study was carried out in orthopaedics department from the month of January 2020 to December 2020, patients with Osteoarthritis of knee stage 1&2 have been included in this study and been followed up till December 2021 and have been evaluated based on WOMAC and VAS score system. Results: Among 31 patients who were willing and consented for study with Osteoarthritis of knee stage 1 (11 Males and 20 Females) the mean WOMAC score and VAS score were improved statistically following intra articular PRP injection. Conclusions: PRP plays an important role in tissue repair, regeneration, and the differentiation of mesenchymal stem cells to treat degenerative lesions of articular cartilage of the knee. This therapy appears to have minimal associated adverse events and have beneficial effects in terms of pain, stiffness, patient satisfaction and better functional outcomes.

Keywords: Intra Articular PRP, Platelet Rich Plasma OA Knee, Osteoarthritis Knee, PRP IN OA Knee, Stage 1 & 2 OA Knee

Edition: Volume 11 Issue 11, November 2022,

Pages: 35 - 39

How to Cite this Article?

Dr Vaibhav Naidu Majji, Dr V Nageswara Rao, Dr Vijay Krishna Adusumalli, "Intra Articular PRP Injection for Stage 1&2 Osteoarthritis of Knee", International Journal of Science and Research (IJSR), Volume 11 Issue 11, November 2022, pp. 35-39,

How to Share this Article?

Similar Articles with Keyword 'Intra'

Downloads: 97 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Orthopaedic Surgery, Kuwait, Volume 5 Issue 5, May 2016

Pages: 1045 - 1048

New Concept of Delayed Open Reduction and Internal Fixation of Closed Recent Intra-articular Calcaneal Fractures

Mohamed M. Abd El-Monem Gafar | Mustafa Taha Al-Akkad | Ahmed Mostafa [2]

Share this Article

Downloads: 1

Research Paper, Orthopaedic Surgery, India, Volume 11 Issue 1, January 2022

Pages: 1536 - 1542

Volar Locking Plate versus External Fixation for Displaced Intra-Articular Distal Radius Fractures: A Prospective Randomized Comparative Study of the Radiological Parameters and Functional Outcomes

Dr. Partha Pratim Chakraborty | Dr. Ayon Ghosh | Dr. Anindya Maiti | Dr. Arumoy Bhuimali | Dr. Aniruddha Mandal | Dr. Kanchan Gurung

Share this Article