International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 1

Masters Thesis | Anaesthesiology | India | Volume 10 Issue 7, July 2021


An Observational Study Comparing Prophylactic Pre - Operative Gabapentin Vs Granisetron for Prevention of Post Operative Nausea and Vomiting in Laparoscopic Abdominal Surgeries

Dr. Rahul Chaudhary, Dr. Chaitri Shah


Abstract: Background: After laparoscopic abdominal surgeries under general anaesthesia, Postoperative nausea and vomiting (PONV) is a common complication. The study was done to evaluate the efficacy of preoperative oral tab. Gabapentin 300mg and Granisetron 0.04mg/kg, administered intravenously for prevention of PONV. Materials and Methods: a prospective, randomized, clinical controlled study was conducted for 1 and 1/2 years, on 60 ASA I & II patients of either sex, aged between 18 to 65 years, planned for laparoscopic abdominal surgery under general anaesthesia. Patients were randomly assigned to one of the two groups, group A (n=30), received oral tab. Gabapentin 300mg 1hour prior to surgery with sips of water and group B (n=30), received Inj. Granisetron 2mg I.V., 2min before induction of anaesthesia. Postoperatively, incidences of nausea, vomiting were noted and any need for rescue antiemetics over 24hrs after surgery were evaluated. Rescue antiemetic drug injection Metoclopramide 10mg IV was given in case of PONV score 2 or more. Results: Both the groups were comparable with respect to demographic features i.e. age, sex, weight, ASA grade, duration of surgery (p>0.05). There was no statistically significant difference between the two groups regarding overall incidence of nausea and vomiting in 24hrs. The incidence of vomiting once in 24hours was 3.33% in Granisetron group and 3.33% in Gabapentin group. The incidence of postoperative vomiting more than once in 24Hours (PONV score 3) is 3.33% in Group A and 3.33% in Group B. This difference is also statistically insignificant with (p-value =1). 73.3% in group A while 66.6% in group B showed complete response to the study drug. Haemodynamically there was no major changes observed in either group. Modified Ramsay sedation score was higher in Gabapentin group compared to Granisetron throughout the various time intervals in the study.


Keywords: PONV, general anesthesia, nausea, vomiting


Edition: Volume 10 Issue 7, July 2021,


Pages: 476 - 482


How to Cite this Article?

Dr. Rahul Chaudhary, Dr. Chaitri Shah, "An Observational Study Comparing Prophylactic Pre - Operative Gabapentin Vs Granisetron for Prevention of Post Operative Nausea and Vomiting in Laparoscopic Abdominal Surgeries", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR21624203919, Volume 10 Issue 7, July 2021, 476 - 482

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'PONV'

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 11, November 2021

Pages: 934 - 937

Comparative Study of Intravenous Ondansetron Vs Dexamethasone in Prevention of Post Operative Nausea and Vomiting for Patients Undergoing General Anesthesia

Dr. Harish Kumar J, Dr. Raj Kumaran .K, Dr. Niranjni, Dr. Lakshmi

Share this Article

Downloads: 123

Research Paper, Anaesthesiology, India, Volume 9 Issue 2, February 2020

Pages: 1262 - 1264

Effectiveness of Prophylactic Intravenous Granisetron for the Prevention of Nausea and Vomiting after Laparoscopic Cholecystectomy: A Prospective Randomized Study

Anuj Kumar, Harshwardhan, Vijay Kr. Sinha, Akhilesh Kumar Singh

Share this Article

Similar Articles with Keyword 'general anesthesia'

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 11, November 2021

Pages: 934 - 937

Comparative Study of Intravenous Ondansetron Vs Dexamethasone in Prevention of Post Operative Nausea and Vomiting for Patients Undergoing General Anesthesia

Dr. Harish Kumar J, Dr. Raj Kumaran .K, Dr. Niranjni, Dr. Lakshmi

Share this Article

Downloads: 27

Case Studies, Anaesthesiology, Indonesia, Volume 10 Issue 3, March 2021

Pages: 1144 - 1146

Effectiveness of Intratracheal 2% Lidocaine Administration to Prevent Post Extubation Phenomenon in Tonsillectomy Surgery in the Central Surgical Installation of Kertha Usada Buleleng Hospital

Kadek Dwipa Dyatmika, I Nyoman Agus Juliana

Share this Article

Similar Articles with Keyword 'nausea'

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 11, November 2021

Pages: 871 - 873

Evaluation of Efficacy of Tramadol and Pethidine for Control of Perioperative Shivering in Patients Undergoing Elective Surgery under Spinal Anaesthesia

Dr. Koti Naveen, Dr Manohar Mane Vilas

Share this Article

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima, Dr M. H. Nagrale

Share this Article

Similar Articles with Keyword 'vomiting'

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima, Dr M. H. Nagrale

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 11, November 2021

Pages: 934 - 937

Comparative Study of Intravenous Ondansetron Vs Dexamethasone in Prevention of Post Operative Nausea and Vomiting for Patients Undergoing General Anesthesia

Dr. Harish Kumar J, Dr. Raj Kumaran .K, Dr. Niranjni, Dr. Lakshmi

Share this Article
Top