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Comparative Studies | Chemistry | Niger | Volume 10 Issue 6, June 2021

Comparative Study of the Quality Control of Metronidazole Sold in Niamey City by Thin Layer Chromatography (TLC)

Salifou Karimoune FADJIMATA ^[2] | Amadou Tidjani ILAGOUMA ^[2]

Abstract: This work describes a comparative analysis study of M?tronidazole sold in Niamey city by Thin Layer Chromatography. This comparison aimed to investigate the quality of on eleven samples distributed as follows which five samples are from pharmacies, five samples are from street vendors and one sample specialty used as reference to check the quality control of them. Chloroform, diethylamine and acetone are the different reagents used. All samples migrated in proposed diluent. This shows that all samples contain the active ingredient substance of M?tronidazole. The percentage of the active ingredient were calculated as per protocol of Clarke?s analysis of drugs and poisons in chemistry guidelines. It varies from 94,4 to 100,4 and 76 to 86 respectively for pharmacies and street vendors. According to the results of the different frontal reports, all sample of pharmacies contains the percentage of active principle recommended by WHO which is 90 to 110 % while none of those from street vendors meet the same WHO standards. This technique can be used for practical work or tutorial and laboratories where drug quality control mechanism is not often checked.

Keywords: Metronidazol, TLC, pharmacies, street vendors, Niamey

Edition: Volume 10 Issue 6, June 2021,

Pages: 1415 - 1417

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