International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064

Downloads: 30

Research Paper | Chemistry | India | Volume 10 Issue 4, April 2021

Ion Chromatography Method Development and Validation for Assay of Sodium Thiosulfate

Chanakya Thaker, Dr. Chetan Chavan, Chetan Chaudhari

A new ion chromatography method was developed, validated and adapted for the assay of Sodium Thiosulfate Pentahydrate as active pharmaceutical ingredient. In this method, separation of Thiosulfate was done using IonPac AS19 column with eluent of 45mM Potassium Hydroxide using suppressed conductivity detection. Thiosulfate was eluted at around 5.3 minutes. Linearity rangeis 1.0 ? 100.0mg/L with regression coefficient value of 0.9999 for Thiosulfate. The Limit of Detection (LOD) value found was 0.15mg/L, and the Limit of Quantification (LOQ) value of 0.06mg/L. Validation parameters examined following suggestions of ICH are accurate ample for the supposed assay. The approach is confirmed as splendid method for assay of Sodium Thiosulfate as active pharmaceutical ingredient with excellent assay percentage values.

Keywords: Ion Chromatography, Suppressor, Conductivity, IonPac AS19, Chromeleon, Sodium Thiosulfate

Edition: Volume 10 Issue 4, April 2021

Pages: 223 - 226

Share this Article

How to Cite this Article?

Chanakya Thaker, Dr. Chetan Chavan, Chetan Chaudhari, "Ion Chromatography Method Development and Validation for Assay of Sodium Thiosulfate", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR21402193550, Volume 10 Issue 4, April 2021, 223 - 226

Enter Your Email Address


Similar Articles with Keyword 'Ion Chromatography'

Downloads: 22 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Chemistry, India, Volume 10 Issue 4, April 2021

Pages: 307 - 312

Quantification of Cyclophosphamide Impurities in Cyclophosphamide Drug Substance and formulations by Ion chromatography

Dr. Chetan Chavan, Chanakya Thaker, Chetan Chaudhari

Share this Article

Downloads: 76

Research Paper, Chemistry, India, Volume 9 Issue 10, October 2020

Pages: 1072 - 1076

Purification and Characterization of Polyphenol Oxidase from Zyzyphus spina-christi from Telangana Region

T R Satyakeerthy, T R Shanthi, Raju Bolla, Lini Nirmala

Share this Article

Similar Articles with Keyword 'Conductivity'

Downloads: 1 | Monthly Hits: ⮙1

Research Paper, Chemistry, India, Volume 10 Issue 8, August 2021

Pages: 548 - 556

Physico Chemical Evolution of Water Quality at Pithampur Industrial Area during 2016 - 2017

Paras Tak, Madhaw Singh Chouhan

Share this Article

Downloads: 2 | Monthly Hits: ⮙2

Research Paper, Chemistry, Nigeria, Volume 10 Issue 8, August 2021

Pages: 1086 - 1089

Organochlorine Residues in the Nigeria Environment: A Study on Residues in Adoka Rice Farm, Benue State

Ogbuagu J. O., Okeke A. P.

Share this Article

Similar Articles with Keyword 'Ion'

Downloads: 53

Research Paper, Chemistry, Nigeria, Volume 2 Issue 3, March 2013

Pages: 457 - 459

Selenium Content in some Brands of Bottled Beer Marketed in Makurdi Town Benue State, Nigeria

A. D. Oklo, R. Sha'Ato, K. Asemave, C.Mkurzurum

Share this Article

Downloads: 127

Research Paper, Chemistry, India, Volume 5 Issue 5, May 2016

Pages: 2066 - 2070

Comparative Study of the Antiurolithiatic Activity of Plant Hydroalcoholic Extract of Argemone mexicana, Cissus javana DC and Garcinia pendunculata

O. Ibopishak Singh, A. Bimola Devi

Share this Article

Similar Articles with Keyword 'Chromatography'

Downloads: 1

Research Paper, Chemistry, Sudan, Volume 10 Issue 5, May 2021

Pages: 444 - 448

Isolation and Structural Elucidation of three Substituted Flavones from Croton Zambesicus (Mull) Fruit and Leaves

Mustafa S.Koya, Nada A. Elamin, Zeinab A. Elrabei

Share this Article

Downloads: 1

Comparative Studies, Chemistry, Niger, Volume 10 Issue 6, June 2021

Pages: 1415 - 1417

Comparative Study of the Quality Control of Metronidazole Sold in Niamey City by Thin Layer Chromatography (TLC)

Salifou Karimoune FADJIMATA, Amadou Tidjani ILAGOUMA

Share this Article
Top