Research Paper | Chemistry | India | Volume 10 Issue 4, April 2021
Ion Chromatography Method Development and Validation for Assay of Sodium Thiosulfate
Chanakya Thaker, Dr. Chetan Chavan, Chetan Chaudhari
A new ion chromatography method was developed, validated and adapted for the assay of Sodium Thiosulfate Pentahydrate as active pharmaceutical ingredient. In this method, separation of Thiosulfate was done using IonPac AS19 column with eluent of 45mM Potassium Hydroxide using suppressed conductivity detection. Thiosulfate was eluted at around 5.3 minutes. Linearity rangeis 1.0 ? 100.0mg/L with regression coefficient value of 0.9999 for Thiosulfate. The Limit of Detection (LOD) value found was 0.15mg/L, and the Limit of Quantification (LOQ) value of 0.06mg/L. Validation parameters examined following suggestions of ICH are accurate ample for the supposed assay. The approach is confirmed as splendid method for assay of Sodium Thiosulfate as active pharmaceutical ingredient with excellent assay percentage values.
Keywords: Ion Chromatography, Suppressor, Conductivity, IonPac AS19, Chromeleon, Sodium Thiosulfate
Edition: Volume 10 Issue 4, April 2021
Pages: 223 - 226
How to Cite this Article?
Chanakya Thaker, Dr. Chetan Chavan, Chetan Chaudhari, "Ion Chromatography Method Development and Validation for Assay of Sodium Thiosulfate", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR21402193550, Volume 10 Issue 4, April 2021, 223 - 226
Similar Articles with Keyword 'Ion Chromatography'
Quantification of Cyclophosphamide Impurities in Cyclophosphamide Drug Substance and formulations by Ion chromatography
Dr. Chetan Chavan, Chanakya Thaker, Chetan Chaudhari
Purification and Characterization of Polyphenol Oxidase from Zyzyphus spina-christi from Telangana Region
T R Satyakeerthy, T R Shanthi, Raju Bolla, Lini Nirmala
Similar Articles with Keyword 'Conductivity'
Physico Chemical Evolution of Water Quality at Pithampur Industrial Area during 2016 - 2017
Paras Tak, Madhaw Singh Chouhan
Organochlorine Residues in the Nigeria Environment: A Study on Residues in Adoka Rice Farm, Benue State
Ogbuagu J. O., Okeke A. P.
Similar Articles with Keyword 'Ion'
Selenium Content in some Brands of Bottled Beer Marketed in Makurdi Town Benue State, Nigeria
A. D. Oklo, R. Sha'Ato, K. Asemave, C.Mkurzurum
Comparative Study of the Antiurolithiatic Activity of Plant Hydroalcoholic Extract of Argemone mexicana, Cissus javana DC and Garcinia pendunculata
O. Ibopishak Singh, A. Bimola Devi
Similar Articles with Keyword 'Chromatography'
Isolation and Structural Elucidation of three Substituted Flavones from Croton Zambesicus (Mull) Fruit and Leaves
Mustafa S.Koya, Nada A. Elamin, Zeinab A. Elrabei
Comparative Study of the Quality Control of Metronidazole Sold in Niamey City by Thin Layer Chromatography (TLC)
Salifou Karimoune FADJIMATA, Amadou Tidjani ILAGOUMA