Ion Chromatography Method Development and Validation for Assay of Sodium Thiosulfate
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

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Research Paper | Chemistry | India | Volume 10 Issue 4, April 2021

Ion Chromatography Method Development and Validation for Assay of Sodium Thiosulfate

Chanakya Thaker, Dr. Chetan Chavan, Chetan Chaudhari

A new ion chromatography method was developed, validated and adapted for the assay of Sodium Thiosulfate Pentahydrate as active pharmaceutical ingredient. In this method, separation of Thiosulfate was done using IonPac AS19 column with eluent of 45mM Potassium Hydroxide using suppressed conductivity detection. Thiosulfate was eluted at around 5.3 minutes. Linearity rangeis 1.0 ? 100.0mg/L with regression coefficient value of 0.9999 for Thiosulfate. The Limit of Detection (LOD) value found was 0.15mg/L, and the Limit of Quantification (LOQ) value of 0.06mg/L. Validation parameters examined following suggestions of ICH are accurate ample for the supposed assay. The approach is confirmed as splendid method for assay of Sodium Thiosulfate as active pharmaceutical ingredient with excellent assay percentage values.

Keywords: Ion Chromatography, Suppressor, Conductivity, IonPac AS19, Chromeleon, Sodium Thiosulfate

Edition: Volume 10 Issue 4, April 2021

Pages: 223 - 226

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Chanakya Thaker, Dr. Chetan Chavan, Chetan Chaudhari, "Ion Chromatography Method Development and Validation for Assay of Sodium Thiosulfate", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR21402193550, Volume 10 Issue 4, April 2021, 223 - 226

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