International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064

Downloads: 40

Research Paper | Medical Microbiology | India | Volume 10 Issue 4, April 2021

Microbiological Trends of Candidemia and Antifungal Susceptibility Pattern: Seven Years Experience at a Multi Super - Specialty Center in Northern India

Eshani Dewan, Vandana Verma

Introduction: The threat of Invasive fungal infections has been increasing in the contemporary health care scenarios, with candidal infections being the most common. Candidal bloodstream infections (BSIs) account for one?fourth of the nosocomial BSIs. Candida albicans once the most common has now been replaced by nonalbicans Candida (NAC), accounting for majority of cases of candidal infections. The knowledge and understanding of specific risk factors, epidemiology, prophylactic measures, and outcomes with relation to speciation are changing rapidly. Emergence of antifungal resistance is a cause of concern. With this background, a retrospective study was undertaken. Aims and Objectives: To isolate Candida spp. from blood cultures of patients with clinically diagnosed or suspected septicemia; to determine incidence of candidemia; to identify and speciate Candida isolates and carry out the antifungal susceptibility test. Materials and Methods: This retrospective study was conducted at the Department of Microbiology, CMC and Hospital, Ludhiana from January 2014 to December 2020. Blood cultures received during this period by BACTEC automated culture system; Becton Dickinson were included in the study. The positive blood culture bottles were cultured on Sabouraud dextrose agar. Recovered Candida isolates were speciated and antifungal susceptibility testing was performed as per Clinical and Laboratory Standards Institute guideline (CLSI). Results: A total of 396 out of 52, 066 blood cultures were culture positive for Candida species. Therefore the overall prevalence rate of isolation of Candida species was 0.76% in our study. The incidence of blood stream infection caused by Non albicans Candida species (72.98%) was higher than Candida albicans (27.02%). Among NAC spp. Candida tropicalis (28.28%) was the most common, followed by Candida parapsilosis (18.94%), Candida glabrata (11.87%), Candida krusei (9.09%), and Candida gullermondii (4.30%) and Candida dubliniensis (0.5%). Candida spp. demonstrated higher resistance to azole group of antifungal agents, as compared to amphotericin B. Resistance was significantly higher among NAC spp. , Itraconazole, Clotrimazole, Fluconazole, Ketoconazole and Amphotericin B- 46.37%, 42.21% 39.10%, 34.60%, and 4.15%, respectively. Conclusion: Species-level identification of Candida and their antifungal sensitivity testing should to be performed to achieve better clinical result and to select an appropriate and effective antifungal therapy. High resistance to antifungal agents is an alarming sign to the healthcare professionals.

Keywords: Blood stream infections, candidemia, Candida albicans, nonalbicans Candida (NAC), Fluconazole, Antifungal resistance

Edition: Volume 10 Issue 4, April 2021

Pages: 110 - 116

Share this Article

How to Cite this Article?

Eshani Dewan, Vandana Verma, "Microbiological Trends of Candidemia and Antifungal Susceptibility Pattern: Seven Years Experience at a Multi Super - Specialty Center in Northern India", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR21331100109, Volume 10 Issue 4, April 2021, 110 - 116

Enter Your Email Address


Similar Articles with Keyword 'Candida albicans'

Downloads: 98

Research Paper, Medical Microbiology, Nigeria, Volume 8 Issue 8, August 2019

Pages: 1702 - 1708

Determination of Azole Resistant Gene (ERG11) in Candida Species Isolated from Non-Pregnant Women Attending Amassoma Community Hospitals, Bayelsa State, Nigeria

Oluwayemisi A. Olorode, Nkechi O. Ezenobi, Bena Stanley

Share this Article

Downloads: 106

Comparative Studies, Medical Microbiology, Iraq, Volume 6 Issue 4, April 2017

Pages: 1100 - 1103

Assessment of Oral Sample Collection Technique for the Isolation of Candida albicans from Patients having Denture Stomatitis

Hadeel Salman Alazzawi, Jamal Noori Ahmed

Share this Article

Similar Articles with Keyword 'Fluconazole'

Downloads: 98

Research Paper, Medical Microbiology, Nigeria, Volume 8 Issue 8, August 2019

Pages: 1702 - 1708

Determination of Azole Resistant Gene (ERG11) in Candida Species Isolated from Non-Pregnant Women Attending Amassoma Community Hospitals, Bayelsa State, Nigeria

Oluwayemisi A. Olorode, Nkechi O. Ezenobi, Bena Stanley

Share this Article

Downloads: 106

Research Paper, Medical Microbiology, India, Volume 6 Issue 4, April 2017

Pages: 1608 - 1609

New Threat in Newborns: Multiresistant Non-Albicans Candidemia

Dr Baishali Chakraborty, Dr Dibyendu Banerjee, Dr Sharmistha Koley, Dr Banya Chakraborty

Share this Article

Similar Articles with Keyword 'Blood'

Downloads: 1

Research Paper, Medical Microbiology, India, Volume 10 Issue 8, August 2021

Pages: 863 - 869

Antimicrobial Susceptibility Pattern of Multi Drug Resistant (MDR) Pseudomonas aeruginosa in a Tertiary Care Hospital from Central India

Manish Patidar, Dr. Naveen Dhingra

Share this Article

Downloads: 4

Review Papers, Medical Microbiology, India, Volume 10 Issue 7, July 2021

Pages: 227 - 230

Novel Coronavirus (COVID-19) - A Review

Adil Raza

Share this Article

Similar Articles with Keyword 'infections'

Downloads: 38

Research Paper, Medical Microbiology, India, Volume 10 Issue 2, February 2021

Pages: 976 - 978

Detection of Pyogenic Infections among Clinical Samples Received in Department of Microbiology in Integral Institute of Medical Sciences and Research, Lucknow, Uttar Pradesh: A Retrospective Analysis

Nikita Mishra, Shilpi Srivastava, Namita Srivastava

Share this Article

Downloads: 92

Research Paper, Medical Microbiology, Afghanistan, Volume 9 Issue 7, July 2020

Pages: 1824 - 1829

Recent Diagnostic Techniques for COVID-19

Dr Mohibullah Salih

Share this Article
Top