Comparison of Risk Factor Profiles and Angiographic Disease Patterns in Premenopausal and Postmenopausal Women Presenting to a Tertiary Care Hospital
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

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Research Paper | Cardiology Science | India | Volume 10 Issue 3, March 2021

Comparison of Risk Factor Profiles and Angiographic Disease Patterns in Premenopausal and Postmenopausal Women Presenting to a Tertiary Care Hospital

Pradeep P. Deshmukh, Tanu Namdeo, Swapnil Bhedodkar, Suresh Sarwale, Anish Kamble

Coronary Artery Disease (CAD) is increasingly becoming the disease of the young. Not much is known regarding the risk factors & pattern of CAD in pre-menopausal Indian women. Aim was to study the differences in risk factor profile and coronary angiographic pattern of disease among pre- & post-menopausal women. Methods: A total of 1260 consecutive female patients who underwent coronary angiogram for suspected ischemic heart disease over a period of 2 years from Jan 2019 to Dec 2020 were enrolled. Patients were divided into 2 groups, premenopausal group consisted of 240 (19.04 %) patients and postmenopausal group 1020 (80.95 %). Detailed risk factor profiles and angiographic patterns of disease were recorded and analyzed. Results: Premenopausal women were more likely to be obese (58.3 % Vs 47 %, p=0.05), hypothyroid (25 % Vs 11 %, p<0.0001) and more likely to have a positive family history of premature CAD (39.7 % Vs 5.89 %, p<0.0001). On the other hand, postmenopausal women were more likely to be diabetic (23.2 % Vs 12.7 %, p=0.007), hypertensive (73.8 % Vs 52.3 %, p<0.0001), smokers (31 % Vs 20 %, p=0.01) and had >3 risk factors more frequently (43.5 % Vs 31 %, p=0.0071). Atypical chest pain was more common as presenting diagnosis among premenopausal women (24.4 % Vs 11.4 %, p<0.0001). They were also more likely to have positive exercise stress test (63.5 % Vs 38.3 %, p<0.0001) and normal coronary angiogram (60.1 % Vs 33.3 %, p<0.00024) with endothelial dysfunction (85.8 % Vs 67.6 %, p<0.0001) than post-menopausal women. Post-menopausal women had greater burden of obstructive CAD characterized by more prevalent multivessel disease in the form of double vessel (18.3 % Vs 7.8 %, p=0.071) & triple vessel disease (21.2 % Vs 6.4 %, p<0.00023). Conclusion: The risk factor profile and angiographic disease pattern among women vary significantly depending on their menopause status. Recognizing these distinctions would aid in a deeper understanding of the connection between m

Keywords: Menopause, Coronary artery disease, Risk factors, Coronary angiography

Edition: Volume 10 Issue 3, March 2021

Pages: 1529 - 1533

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Pradeep P. Deshmukh, Tanu Namdeo, Swapnil Bhedodkar, Suresh Sarwale, Anish Kamble, "Comparison of Risk Factor Profiles and Angiographic Disease Patterns in Premenopausal and Postmenopausal Women Presenting to a Tertiary Care Hospital", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR21324143636, Volume 10 Issue 3, March 2021, 1529 - 1533

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