International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




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Research Paper | Paediatrics | India | Volume 10 Issue 3, March 2021


Congenital CMV Meningitis in an Immunocompetant Infant with Hirschsprung's Disease - A Case Report

Dr. Vaishnavi Bhagat | Dr. Rajesh Kulkarni | Dr. Aarti Kinikar


Abstract: Cytomegalovirus (CMV) is a common perinatal infection that tends to follow a silent course and only 5?15% of CMV-infected infants are symptomatic at birth, with signs and symptoms characterized by the involvement of multiple organs, particularly the reticuloendothelial and central nervous systems. (1, 2)Gastrointestinal involvement is considered rare, and may vary depending on the location and extent of the disease, with different manifestations. (1, 2, 3, 4, 5, 6)Few studies have also reported etiological association of Hirschsprung's disease with congenital CMV infection, due to damage of myentric plexus by the virus causing aganglinosis. (1, 5, 6). We report a case of coexistence of congenital CMV infection in the form of CMV meningitis with Hirschsprung's disease in a male infant born at 39 weeks gestation. The serologic data and DNA PCR report suggested a CMV infection of CNS and the pathologic findings of resected bowel specimens showed hypoganglionosis. Our report shows congenital CMV infection may be etiologically associated with Hirschsprung disease.


Keywords: Congenital CMV infection, Hirschprung's disease, immunocompetent infant


Edition: Volume 10 Issue 3, March 2021,


Pages: 844 - 846


How to Cite this Article?

Dr. Vaishnavi Bhagat, Dr. Rajesh Kulkarni, Dr. Aarti Kinikar, "Congenital CMV Meningitis in an Immunocompetant Infant with Hirschsprung's Disease - A Case Report", International Journal of Science and Research (IJSR), Volume 10 Issue 3, March 2021, pp. 844-846, https://www.ijsr.net/get_abstract.php?paper_id=SR21226101642

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