COVID-19 and its Effect on Coagulation Profile: A Systematic Review
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Medical Science | India | Volume 10 Issue 2, February 2021

COVID-19 and its Effect on Coagulation Profile: A Systematic Review

Parul Goel, Gagandeep Malik

Introduction: Corona Virus Disease (COVID-19) is a global pandemic and has become a major threat to health care system across the world. Majority of the cases present with mild symptoms but in some cases there is progression to Acute Respiratory Distress Syndrome (ARDS) leading to death. The major concern associated with COVID-19 is the fatality associated with infection. To prevent such an adverse incident there is an urgent need to identify biomarkers that effectively and timely determine the likelihood of progression to critical form of disease. Coagulopathy is common in COVID-19 patients with severe/critical form of disease. This review article aims to explore coagulation profile in COVID-19 patients and to correlate the same with the severity of illness. Material & Methods: A systematic search of published articles from January 1 to July 1, 2020 on COVID-19 was performed for identifying abnormalities in coagulation parameters in COVID-19 patients. Individual articles were screened and thereafter data was collected as per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: A total of 163 articles on COVID-19 were screened from which only 60 articles with various laboratory parameters including coagulation profile were finally included in the review. Conclusion: Coagulopathy in COVID-19 patients has been found to be associated with an increased risk of death. Various evidences such as elevated levels of D-dimers, Fibrinogen, prolonged Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and thrombocytopenia can help clinicians in risk stratification and early prediction of progression to severe/fatal form of COVID-19. Key words: COVID-19, D-dimers, Thrombocytopenia, Fibrinogen, Prothrombin Time, Activated Partial Thromboplastin Time. Key points:  COVID-19 caused by Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) has reached pandemic levels.  Patients with COVID-19 have high

Keywords: COVID-19, D-dimers, Thrombocytopenia, Fibrinogen, Prothrombin Time, Activated Partial Thromboplastin Time

Edition: Volume 10 Issue 2, February 2021

Pages: 115 - 130

Share this Article

How to Cite this Article?

Parul Goel, Gagandeep Malik, "COVID-19 and its Effect on Coagulation Profile: A Systematic Review", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR21129104552, Volume 10 Issue 2, February 2021, 115 - 130

89 PDF Views | 69 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'COVID-19'

Informative Article, Medical Science, India, Volume 9 Issue 4, April 2020

Pages: 1590 - 1590

Idea to Fight COVID-19

Mohammad Mamoon Jan

Share this Article

Research Paper, Medical Science, Indonesia, Volume 10 Issue 2, February 2021

Pages: 972 - 975

Analytical Correlation of D-dimer as Coagulation Biomarker with C-Reactive Protein, Neutrophil Lymphocyte Ratio, and Absolute Lymphocyte Count as Inflammatory Biomarker in COVID-19 Patient: A Retrospective Study

Kadek Surya Atmaja, I Gede Dilajaya Robin, Wayan Wahyu Semara Putra, Ni Made Dwita Yaniswari

Share this Article

Research Paper, Medical Science, India, Volume 10 Issue 2, February 2021

Pages: 697 - 698

Privative Majors of Arsenicum Album - 30 in COVID-19 in All Age Groups

Dr. Sangita S. Anwat, Dr. Swati B. Jadhav

Share this Article

Research Paper, Medical Science, India, Volume 10 Issue 1, January 2021

Pages: 848 - 850

Evaluation of Size of Thymus and its Relationship with CT Severity Score in Patients having CT Signs for COVID 19 Virus Disease in the Age Group of 20-40 Years: A Study of 100 Cases

Dr Devanshee H Jadeja, Dr Bhaven Shah

Share this Article

Case Studies, Medical Science, Indonesia, Volume 10 Issue 2, February 2021

Pages: 380 - 383

New Event NSTEMI in Severe-Critical COVID-19 Patient: Case Report

Jason Raymond Hotama, Yesicha Kurniawati, I Wayan Sunaka, Wayan Wahyu Semara Putra

Share this Article

Similar Articles with Keyword 'Thrombocytopenia'

Research Paper, Medical Science, India, Volume 10 Issue 2, February 2021

Pages: 115 - 130

COVID-19 and its Effect on Coagulation Profile: A Systematic Review

Parul Goel, Gagandeep Malik

Share this Article

Research Paper, Medical Science, India, Volume 8 Issue 12, December 2019

Pages: 1080 - 1084

Dengue with Bradycardia: Clinical Predictors and Prognostic Significance

Dr Karun Mammen Philip, Dr Smitha Bhat

Share this Article

Case Studies, Medical Science, India, Volume 8 Issue 8, August 2019

Pages: 1296 - 1298

A Rare Case of Pneumonia Evolving into Atypical Haemolytic Uremic Syndrome

Rishikesh Dessai, Vinus Taneja, Manishi Nauteyal, Ambuj Garg

Share this Article

Research Paper, Medical Science, India, Volume 9 Issue 2, February 2020

Pages: 1810 - 1815

A Study of Usage of Fresh Frozen Plasma in Liver Diseases and its Effect on PT and INR in Post Transfusional State

Dr. Vijay Kapse, Dr. Vishal Kulkarni, Dr. Renuka Gahine, Dr. Jyoti Chaudhary

Share this Article

Research Paper, Medical Science, India, Volume 8 Issue 12, December 2019

Pages: 1041 - 1043

A Study of Mean Platelet Volume as a Prognostic Marker in Sepsis

Dr. Harish.T. J, Dr. Balaraj K. P., Dr. Bharath.K, Dr. Prabhu.P

Share this Article

Similar Articles with Keyword 'Fibrinogen'

Research Paper, Medical Science, India, Volume 10 Issue 2, February 2021

Pages: 115 - 130

COVID-19 and its Effect on Coagulation Profile: A Systematic Review

Parul Goel, Gagandeep Malik

Share this Article

Research Paper, Medical Science, India, Volume 9 Issue 2, February 2020

Pages: 1810 - 1815

A Study of Usage of Fresh Frozen Plasma in Liver Diseases and its Effect on PT and INR in Post Transfusional State

Dr. Vijay Kapse, Dr. Vishal Kulkarni, Dr. Renuka Gahine, Dr. Jyoti Chaudhary

Share this Article

Similar Articles with Keyword 'Prothrombin Time'

Research Paper, Medical Science, India, Volume 10 Issue 2, February 2021

Pages: 115 - 130

COVID-19 and its Effect on Coagulation Profile: A Systematic Review

Parul Goel, Gagandeep Malik

Share this Article

Research Paper, Medical Science, India, Volume 9 Issue 2, February 2020

Pages: 1810 - 1815

A Study of Usage of Fresh Frozen Plasma in Liver Diseases and its Effect on PT and INR in Post Transfusional State

Dr. Vijay Kapse, Dr. Vishal Kulkarni, Dr. Renuka Gahine, Dr. Jyoti Chaudhary

Share this Article
Top