International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Reviewed

ISSN: 2319-7064


Downloads: 9 | Weekly Hits: ⮙2 | Monthly Hits: ⮙3

Informative Article | Medical Microbiology | India | Volume 11 Issue 1, January 2022


Methicillin Resistant S. aureus (MRSA) Bacteremia: A Case Series and the Clinical Implications of Vancomycin MIC Creep

Gohel Swati Y | Praveen B [6] | Thirunarayanan M A | Ramasubramanian V | Senthur Nambi P | Gopalakrishnan R


Abstract: Purpose: Methicillin resistant S. aureus (MRSA) bacteremia carries high morbidity and mortality. Very few studies from India have looked into the clinical features and outcome of MRSA bacteremia, at the same time some studies have noticed significant vancomycin MIC creep amongst MRSA isolates. Materials and Methods: It is a retrospective observational study conducted at a tertiary care centre over a period of five years, describing clinical characteristics and outcome of patients with MRSA bacteremia and attempted to analyse clinical implications of vancomycin MIC creep in MRSA bacteremia. Results: A total of 60 cases of MRSA bacteremia were studied. Prior antibiotic exposure (63.3%), recent hospitalisation (61.7%) and diabetes mellitus (40%) were the commonest potential risk factors. Fifteen percent of the study population had persistent bacteremia. There was no statistically significant difference in outcome between vancomycin and teicoplanin as empirical antibiotics. Our study demonstrated an increase in percentage of isolates with MIC ? 1 from 2011 to 2015. On an attempt to analyse clinical implication of this creep we found no statistically significant difference between high (MIC ? 1) and low (MIC<1) vancomycin MIC groups. Conclusion: We conclude that MRSA bacteremia is a serious infection with most patients requiring ICU admission, with almost one in seven patients having persistent bacteremia and an overall mortality rate of 16 percent. With a rise in vancomycin MIC further randomised studies are needed to see its clinical implication.


Keywords: MRSA, bacteremia, Vancomycin, MIC creep, Staphylococcus aureus


Edition: Volume 11 Issue 1, January 2022,


Pages: 31 - 36


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

Gohel Swati Y, Praveen B, Thirunarayanan M A, Ramasubramanian V, Senthur Nambi P, Gopalakrishnan R, "Methicillin Resistant S. aureus (MRSA) Bacteremia: A Case Series and the Clinical Implications of Vancomycin MIC Creep", International Journal of Science and Research (IJSR), Volume 11 Issue 1, January 2022, pp. 31-36, https://www.ijsr.net/get_abstract.php?paper_id=SR211229054238

Similar Articles with Keyword 'MRSA'

Downloads: 0

Student Project, Medical Microbiology, Kenya, Volume 11 Issue 8, August 2022

Pages: 762 - 765

Occurrence of Post-Surgical Wound Infections, Bacterial Isolates, and their Susceptibility to Commonly Used Antibiotics at Kenyatta National Hospital, Kenya

Magdaline Burugu | Andrew Nyerere | Susan Odera | Lameck Ontweka

Share this Article

Downloads: 51

Research Paper, Medical Microbiology, Egypt, Volume 10 Issue 3, March 2021

Pages: 1389 - 1395

Synergistic Antimicrobial Effect of Egyptian Honey with Antibiotics and Its Capability to Restore MRSA Sensitive to Oxacillin

Abdul-Hafeez M. M. | Hamouda .S .M | Abd El Rahman M. F.

Share this Article
Top