International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 48

Masters Thesis | Biomedical Sciences | Indonesia | Volume 10 Issue 1, January 2021


Intermittent Fasting with Moderate-Intensity Physical Exercise Increased Melatonin but Did Not Reduce Body Mass Index in Obese Rats

Novana O. Mantiri, Wimpie Pangkahila, Alex Pangkahila


Abstract: Background: Intermittent Fasting (IF) is a dietarymethod studied to positively affect circadian rhythm and metabolism by increasing melatonin hormone that may promote weight loss in obese individuals. Objective: This study aimed to measure IF with moderate-intensity exercise on increasing melatonin levels and reduce Body Mass Index (BMI). Methodology: An experimental study with pre and post-test control group design was conducted on 36 obese male Wistar rats aged 4-5 months. The subjects weredivided randomly into two groups, the study and control groups, with 18 subjects in each group. The study group underwent IF for 12 hours with moderate-intensity physical exercise, while the control group was given a standard diet with moderate-intensity physical exercise. After four weeks of intervention, melatonin levels assessedusing ELISA (enzyme-linked immunosorbent assay) ; meanwhile, BMI was measured before and after treatment. The comparative test was conducted to compare the results between groups. Results: The results showed that the mean pretest and post-test melatonin levels in the study group increased significantly (0.3530.01vs.0.4790.01; p<0.001). Melatonin levels in the study group at the end of the study also showed a significant increase compared to the control group (0.1940.03 vs.0.4790.01; p<0.001). However, the mean pretest and post-test BMI in the study group did not show any significant differences (0.3530.01 vs.0.3510.0; p=0.965). The BMI comparison between the study and control groups also did not show any significant differences (0.3510.01 vs.0.3540.01; p=0.432). Conclusion: IF with moderate-intensity exercise increased melatonin levels but did not reduce BMI in obese male Wistar rats. The duration and diet regimes of IF need to be further evaluated.


Keywords: Intermittent fasting, Obesity, Melatonin, Body mass index, Metabolism, Moderate physical activity


Edition: Volume 10 Issue 1, January 2021,


Pages: 786 - 789


How to Cite this Article?

Novana O. Mantiri, Wimpie Pangkahila, Alex Pangkahila, "Intermittent Fasting with Moderate-Intensity Physical Exercise Increased Melatonin but Did Not Reduce Body Mass Index in Obese Rats", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR21112182656, Volume 10 Issue 1, January 2021, 786 - 789

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Obesity'

Downloads: 74

Masters Thesis, Biomedical Sciences, Indonesia, Volume 9 Issue 11, November 2020

Pages: 1461 - 1464

Combination of Spirulina Supplementation and Moderate Physical Activity Reduced Weight, Abdominal Fat and Malondialdehyde in Obese Rats

Cynthia Jayanto, Wimpie Pangkahila, Alex Pangkahila

Share this Article

Downloads: 102

Review Papers, Biomedical Sciences, India, Volume 6 Issue 5, May 2017

Pages: 1683 - 1684

Microbiome and Cancer

Nivaasini Sivarajah

Share this Article

Similar Articles with Keyword 'Body mass index'

Downloads: 94

Review Papers, Biomedical Sciences, India, Volume 9 Issue 6, June 2020

Pages: 828 - 831

Estimation of Albumin and Globulin in Pre and Post Radio-Therapeutic Patients: A Review

Aakriti Chourasia, Alibha Rawat, N. Ganesh

Share this Article

Downloads: 117

Research Paper, Biomedical Sciences, Indonesia, Volume 7 Issue 3, March 2018

Pages: 1148 - 1150

Assessment of Serum Leptin among Patients with Skin Tag in Dr. Mohammad Hoesin General Hospital Palembang

Yuli Kurniawati, Mutia Devi, Khairani

Share this Article

Similar Articles with Keyword 'Metabolism'

Downloads: 74

Masters Thesis, Biomedical Sciences, Indonesia, Volume 9 Issue 11, November 2020

Pages: 1461 - 1464

Combination of Spirulina Supplementation and Moderate Physical Activity Reduced Weight, Abdominal Fat and Malondialdehyde in Obese Rats

Cynthia Jayanto, Wimpie Pangkahila, Alex Pangkahila

Share this Article

Downloads: 119

Research Paper, Biomedical Sciences, Nigeria, Volume 7 Issue 12, December 2018

Pages: 744 - 747

Lipid Testing among Patients with Type 2 Diabetes who was About to Commence Treatment at a Tertiary Health Care

Ngwu Amauche Martina, Ifeanyichukwu Martin Ositadinma, Aniagolu Miriam O., Kamah Jude Maduabuchi

Share this Article

Similar Articles with Keyword 'fasting'

Downloads: 92

M.Tech / M.E / PhD Thesis, Biomedical Sciences, Indonesia, Volume 6 Issue 4, April 2017

Pages: 428 - 432

Low Serum Uric Acid Level Increased the Risk of Parkinsons Disease

Kadek Trisnadewi, Wimpie I Pangkahila, Thomas Eko Purwata, I Putu Eka Widyadharma

Share this Article

Downloads: 119

Research Paper, Biomedical Sciences, Nigeria, Volume 7 Issue 12, December 2018

Pages: 744 - 747

Lipid Testing among Patients with Type 2 Diabetes who was About to Commence Treatment at a Tertiary Health Care

Ngwu Amauche Martina, Ifeanyichukwu Martin Ositadinma, Aniagolu Miriam O., Kamah Jude Maduabuchi

Share this Article
Top