International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 1

Research Paper | Chemistry | India | Volume 10 Issue 2, February 2021


Synthesis of 1-Acetyl-5-Substitutedaryl-3-[5?-(5??-Methoxy-3?-Indomethyl)-2?-Amino-1?, 3?, 4?-Thiadiazol-2?-N-Yl]-2-Pyrazoline Derivatives as Potent Anti-Inflammatory Agent

Anil Kumar [110]


Abstract: When 5-(5?-methoxy-3?-indomethyl)--1?, 3?, 4?-thiadiazol-2?-amino substituted chalcones (5a-5e) undergo cyclisation in presence of 99% hydrazine hydrate and few drops of glacial acetic acid and refluxed for 12 hours, a novel series of 1-acetyl-5-substitutedaryl-3-[5?-(5??-methoxy-3?-indomethyl)-2?-amino-1?, 3?, 4?-thiadiazol-2?-N-yl]-2-pyrazoline can be synthesised. These compounds were characterised by IR, NMR spectroscopy and screened for their promising anti-inflammatory activity.


Keywords: Thiadiazol, Indole, Chalcones, Pyrazoline, anti anti-inflammatory activity


Edition: Volume 10 Issue 2, February 2021,


Pages: 1692 - 1697

Synthesis of 1-Acetyl-5-Substitutedaryl-3-[5?-(5??-Methoxy-3?-Indomethyl)-2?-Amino-1?, 3?, 4?-Thiadiazol-2?-N-Yl]-2-Pyrazoline Derivatives as Potent Anti-Inflammatory Agent


How to Cite this Article?

Anil Kumar, "Synthesis of 1-Acetyl-5-Substitutedaryl-3-[5?-(5??-Methoxy-3?-Indomethyl)-2?-Amino-1?, 3?, 4?-Thiadiazol-2?-N-Yl]-2-Pyrazoline Derivatives as Potent Anti-Inflammatory Agent", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR21111172532, Volume 10 Issue 2, February 2021, 1692 - 1697, #ijsrnet

How to Share this Article?

Enter Your Email Address




Similar Articles with Keyword 'Thiadiazol'

Downloads: 103

Research Paper, Chemistry, Iraq, Volume 3 Issue 12, December 2014

Pages: 2670 - 2677

Synthesis & Spectroscopic Study of Ni (II), Cu (||), Co (|||), Cr (|||) &Fe (|||) Complexes with 1, 3, 4-thiadiazol

Fatimah Abdul Hasan Nader AL-Ghazzawi

Share this Article

Downloads: 107

Research Paper, Chemistry, Iraq, Volume 4 Issue 10, October 2015

Pages: 2012 - 2018

Synthesis of New ?-Adrenergic Blocking Agents Having Heterocyclic Moiety with Expected Activity

Ekhlass T. Soore | Ahlam J. Qasir [2]

Share this Article


Top