Pheochromocytoma - Histopathological and Clinical Update
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064



Downloads: 132 | Monthly Hits: ⮙1

Research Paper | Pathology | India | Volume 9 Issue 9, September 2020

Pheochromocytoma - Histopathological and Clinical Update

Dr. Asima Ajaz, Dr. Huzaifa Tak, Dr Iqbal Lone

Background: The pheochromocytoma or paraganglioma PPGL is a metabolically active tumor originating from the chromaffin cells of adrenal medulla (pheochromocytomas) or from sympathetic or parasympathetic autonomic ganglia (paragangliomas). The exact incidence of pheochromocytoma is unknown, but it is estimated to occur in 2–8 cases per 1 million people per year. The estimated prevalence in hypertensive adults is thought to range from 0.1 to 0.6 %. The foremost investigation is ususally increased urinary and plasma levels of catecholamines and their metabolites (metanephrines, normetanephrines & VMA). Histopathological and IHC features are accustomed to authenticate the diagnosis. Aim: In this study, the most frequently diagnosed tumor of adrenal gland-Pheochromocytoma along with their detailed histopathological, biochemical and clinical characterstics were studied in detail. Material and Method: A retrospective 5 year study was carried out. Brief clinical history was taken along with other relevant parameters. Histopathological data was collected and relevant details were noted. The clinical and findings of H & E sections, special stains and IHC were compiled to arrive at a final diagnosis. Results: Out of 70 cases of adrenal masses, pheochromocytoma (31 cases) was the most common tumor observed. The most common symptom was hypertension. CT scan done on 28 cases showed greater enhancement on contrast phase. The 24-hr urinary levels of VMA was elevated in 16 (51.6 %). Confluent necrosis was present in 14 cases and 3 cases showed vascular invasion histologically. Pass score was ≥4 in 9cases and <4 in remaining 22cases. IHC panel used show positivity for Chromogranin, S-100, synaptophysin. Conclusion: We conclude that the following clinicopathological parameters should be taken into account for proper diagnosis and risk assessment of malignant behavior of pheochromocytoma. - proper clinical evaluation biochemical markers, location, size, PASS score, IHC markers.

Keywords: Pheochromocytoma, hypertension, VMA, PASS score, IHC markers

Edition: Volume 9 Issue 9, September 2020

Pages: 244 - 250

Share this Article

How to Cite this Article?

Dr. Asima Ajaz, Dr. Huzaifa Tak, Dr Iqbal Lone, "Pheochromocytoma - Histopathological and Clinical Update", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR20830100222, Volume 9 Issue 9, September 2020, 244 - 250

Enter Your Email Address




Similar Articles with Keyword 'hypertension'

Downloads: 109

Research Paper, Pathology, India, Volume 3 Issue 7, July 2014

Pages: 668 - 671

Evaluation of Pre-Donation Deferral Causes in Whole Blood Donor Population at a Tertiary Rural Health Centre

Dr. Vamseedhar Annam, Dr. NaliniMohan.C, Dr. Lakshmi.R, Dr. Mrinalini.V.R, Dr. Sivachandran

Share this Article

Downloads: 114

Review Papers, Pathology, India, Volume 7 Issue 7, July 2018

Pages: 1270 - 1274

Is PCOS An Early Manifestation of the Metabolic Syndrome? A Review Article with Latest Updates in the Laboratory Diagnosis, Prevention and Management

Mirza Asif Baig

Share this Article

Similar Articles with Keyword 'IHC markers'

Downloads: 126

Research Paper, Pathology, India, Volume 8 Issue 6, June 2019

Pages: 823 - 826

Pathologic Panorama of Glial Tumours in Atertiary Care Centre - Three Years Institutional Study

Dr. K. Vani, Dr. K. Rama

Share this Article

Downloads: 152

Research Paper, Pathology, India, Volume 5 Issue 12, December 2016

Pages: 184 - 188

Molecular Evaluation of Subtypes of Breast Cancer by Immunohistochemical expression of Estrogen Receptor(ER), Progesterone Receptor(PR), Her2neu,Cytokeratin 5/6 and Ki 67

Shweta Mahajan, Amarjit Singh, Anita Joneja, Sudershan Kapoor

Share this Article



Top