Analytical Method Development and Validation for the Determination of Isoniazid in, Isoniazid and Ethambutol Hydrochloride Tablets
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Research Paper | Chemistry | India | Volume 9 Issue 7, July 2020

Analytical Method Development and Validation for the Determination of Isoniazid in, Isoniazid and Ethambutol Hydrochloride Tablets

Viswanatha Reddy, Vishal Shinde, Anjali A. Rajbhoj, Suresh T. Gaikwad

A simple method using HPLC system for the quantification of Isoniazid, in a fixed-dose combination (FDC) of anti-tuberculosis drug product was developed and validated. The chromatographic separation of Isoniazid (INH) was carried out using Waters Symmetry C8 column (150× 4.6 mm: Particle size: 5 μm), UV detection at 262 nm, and an isocratic system with composed of mobile phase of Phosphate buffer solution (pH 6.8) and Acetonitrile in the ratio of 980: 20, at a flow rate of 1.0 mL/min. The retention time of Isoniazid was about 3.8 minutes.

Keywords: Antituberculosis, Isoniazid, Ethambutol Hydrochloride, HPLC method

Edition: Volume 9 Issue 7, July 2020

Pages: 1876 - 1880

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Viswanatha Reddy, Vishal Shinde, Anjali A. Rajbhoj, Suresh T. Gaikwad, "Analytical Method Development and Validation for the Determination of Isoniazid in, Isoniazid and Ethambutol Hydrochloride Tablets", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR20728070058, Volume 9 Issue 7, July 2020, 1876 - 1880

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