International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 88 | Views: 96

Review Papers | Biomedical Sciences | India | Volume 9 Issue 6, June 2020

Analysis of Sub-Mucous Fibrosis and Micronucleus in Tobacco and Supari Users: A Review

Chetna Singh | Alibha Rawat [14] | N. Ganesh [16]

Abstract: Introduction: Oral cancer is one of the most prevalent cancers worldwide including India. The most common cause of oral cancer has been established as tobacco chewing. Tobacco and Supari are chewed by people all over the world. But the long-time consumption of tobacco and Supari can lead to many diseases related to mouth like Trismus (reduced opening of the jaw), oral leukoplakia, erythroplakia that can eventually develop into oral cancer. OSF (oral sub-mucous fibrosis) is a precancerous condition that can develop into squamous cell carcinoma. Chewing of areca nut can also damage the exfoliated cell of buccal mucosa in which the frequency of micronucleus, an indicator of genetic damage increase as well as increased cytogenetic damage can be seen in the peripheral blood lymphocytes and exfoliated buccal mucosal cells of pan masala chewers. The current review work explores the role of tobacco and supari chewing habits in causing precancerous lesions that have the potential to ultimately develop into oral cancer. Methods: We conducted a thorough electronic search by Cochrane, EMBASE and PubMed to identify relevant studies. Studies published on the role of tobacco and supari and such products on the development of oral sub-mucous fibrosis and eventually oral cancer were included. Studies on micronucleus assay in reference to oral cancer development were also included. After assessing and selecting articles based on eligibility criteria, studies were analyzed and elaborated according to the objective. Results: The various studies successfully established the huge role that tobacco and supari products play in the carcinogenesis process and early prelesions are significant in these users that can be utilized for early diagnosis and treatment.

Keywords: Areca nut, buccal mucosal cells, fibrosis, micronucleus MN, oral disease tobacco, squamous cell carcinoma

Edition: Volume 9 Issue 6, June 2020,

Pages: 807 - 809

How to Download this Article?

Type Your Email Address below to Download the Article PDF

How to Cite this Article?

Chetna Singh, Alibha Rawat, N. Ganesh, "Analysis of Sub-Mucous Fibrosis and Micronucleus in Tobacco and Supari Users: A Review", International Journal of Science and Research (IJSR), Volume 9 Issue 6, June 2020, pp. 807-809,

Similar Articles with Keyword 'fibrosis'

Downloads: 0

Masters Thesis, Biomedical Sciences, Indonesia, Volume 11 Issue 2, February 2022

Pages: 627 - 636

Balinese Green Arabica Coffee Bean (Coffea arabica) Extract Did Not Prevent the Increase of Malondialdehyde Level and Progressivity of Non-Alcoholic Fatty Liver Disease in Male Wistar Rats (Rattus norvegicus) Induced High Calorie Diet

Rynda [2] | I Gusti Made Aman [5] | Ni Putu Sriwidyani [8]

Share this Article

Downloads: 104

Review Papers, Biomedical Sciences, India, Volume 7 Issue 8, August 2018

Pages: 1244 - 1250

Carbon Nanotubes as Delivery System in Combating Diseases

Ardhendu Kumar Mandal

Share this Article