International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


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Research Paper | Chemistry | India | Volume 9 Issue 6, June 2020


Synthesis, Structure Elucidation and Assessment of Microbial Activity of Schiff Bases derived from Condensation of 2-(2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide with Aldehyde Derivatives

Alka Pradhan, Anil Kumar Koshal


Abstract: Some pharmacologically active novel Schiff Bases derived by condensation of 2- (2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide with various aldehyde derivatives by using catalytically amount of glacial acetic acid. Such compounds were elucidated by different physico-chemical techniques like, melting point, IR, 13CNMR, mass, elemental analysis. The novel Schiff bases bearing coumarin moiety have been screened for their anti-microbial activity by disc diffusion method. The Schiff base derivative of N- [ (2-hydroxyphenyl) methylidene]-2- (2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide (IIb) and N- [ (4-nitrophenyl) methylidene]-2- (2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide (IIc) show more potent anti-microbial activities compared with its other derivatives.


Keywords: Condensation, Structure elucidation, Anti-microbial


Edition: Volume 9 Issue 6, June 2020,


Pages: 84 - 87


How to Cite this Article?

Alka Pradhan, Anil Kumar Koshal, "Synthesis, Structure Elucidation and Assessment of Microbial Activity of Schiff Bases derived from Condensation of 2-(2-oxo-2H-1-benzopyran-3-carbonyl) hydrazine-1-carboxamide with Aldehyde Derivatives", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR20529170048, Volume 9 Issue 6, June 2020, 84 - 87

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