International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 96

Research Paper | Pharmacology and Toxicology | Benin | Volume 9 Issue 5, May 2020


Safety of the Ethanolic Extract Crateva adansonii DC. (Capparidaceae) Harvested at Dassa-Zounm? in Central Benin

Zinsou Franck Mignanwande, Armelle Sabine Yelignan Hounkpatin, Roch Christian Johnson, Luc Brun, Armel Geraldo Houndeton, Eustache Enock Houeto


Abstract: Medicinal plants are widely used worldwide by populations and are a source of new active components. The objective of this work is to assess the toxicity of the ethanolic extract of this plant in order to promote its use in traditional medicine in Benin. Method: The ethanolic extract was obtained after evaporation of the filtrate under vacuum on a rotary evaporator. The toxicity studies took into account on the one hand the determination of heavy metals (Pb, Cd and As) on the other hand the Acute and subacute Toxicities which were carried out according to the OECD guidelines respectively Standards 423 and 407 on Wistar strain female rats. Blood samples were taken from animals for hematological and biochemical analyzes. Finally the organs (liver and kidney) were removed for histological readings. Results: The study of the acute oral toxicity of the ethanolic extract of Crateva adansonii at the single dose of 5.000 mg. kg-1 of body weight recorded no death or sign of toxicity during the 14 days of the experimental period. . This shows that the LD50 of our extract is greater than 5.000 mg. kg-1 pc. As for the subchronic toxicity, it revealed that whatever the dose of the extract administered, no signs of intoxication were observed during the 28 days. The extract Crateva adansonii is therefore not lethal. With the exception of a few rare tubular vacuolar degenerations, rats present a hepatic and renal histological appearance within normal limits. Conclusion: This allows us to conclude the ad hoc use of Crateva adansonii is safe but its prolonged use can be harmful to the human organism.


Keywords: Toxicity, acute, subchronic, histology, Crateva adansonii, heavy metals, Safety, Benin


Edition: Volume 9 Issue 5, May 2020,


Pages: 975 - 983


How to Cite this Article?

Zinsou Franck Mignanwande, Armelle Sabine Yelignan Hounkpatin, Roch Christian Johnson, Luc Brun, Armel Geraldo Houndeton, Eustache Enock Houeto, "Safety of the Ethanolic Extract Crateva adansonii DC. (Capparidaceae) Harvested at Dassa-Zounm? in Central Benin", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR20509163948, Volume 9 Issue 5, May 2020, 975 - 983

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Toxicity'

Downloads: 3 | Monthly Hits: ⮙2

Review Papers, Pharmacology and Toxicology, India, Volume 10 Issue 11, November 2021

Pages: 734 - 741

Herbal Drugs Used In Anti - Psychotic Activity: A Review

Dr. Virendra Kumar Sharma, Anurag Singh, Ajay Diwaker, Ankita Wal

Share this Article

Downloads: 87

Research Paper, Pharmacology and Toxicology, India, Volume 9 Issue 7, July 2020

Pages: 1467 - 1469

Mechanism of Action of Hepatotoxicity Drugs

M. Meghana, K. Krishna

Share this Article

Similar Articles with Keyword 'acute'

Downloads: 119

Research Paper, Pharmacology and Toxicology, Burkina Faso, Volume 8 Issue 8, August 2019

Pages: 1361 - 1366

Phytochemical Screening, Acute Toxicity and Anti-Diarrhoeal Effect of Extracts from Prosopis africana (Guill. & Perr.) Taub (Mimosaceae)

Gaetan D. SOMDA, Geoffroy G. OUEDRAOGO, Sylvain ILBOUDO, Noufou OUEDRAOGO, Jean KOUDOU, Pierre I. GUISSOU

Share this Article

Downloads: 127

Research Paper, Pharmacology and Toxicology, United States of America, Volume 9 Issue 1, January 2020

Pages: 1390 - 1403

Effects of Dietary Probiotic (Lactobacillus acidophilus) on Hematology, Blood Biochemistry and Lipid Profile of Carbon Tetrachloride-Induced Toxicity in Rats

M.G.A.EL.Sayed, Enas. A. H. Farag, Heba. M. Nasr

Share this Article

Similar Articles with Keyword 'Safety'

Downloads: 110

Research Paper, Pharmacology and Toxicology, India, Volume 8 Issue 6, June 2019

Pages: 1453 - 1458

Evaluation of Efficacy and Safety of Test Drug in Liver Disorder Subjects with Abnormal Liver Function Test (LFT) - An Open Labeled, Multicenter, Non-Comparative, Interventional, Prospective Clinical Study

Vinod Kuber, Gayatri Ganu, Gunvant Yeola, Narendra Mundhe

Share this Article

Downloads: 182

Review Papers, Pharmacology and Toxicology, India, Volume 8 Issue 2, February 2019

Pages: 473 - 475

Noval Oral Anticoagulants - Review of Articles

Mukunda Kumar, Nishant Sinha, Sumedha Gargy, Danish Nadeem

Share this Article
Top