International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Case Studies | Medicine | India | Volume 9 Issue 4, April 2020

Analysis of Adverse Drug Reactions and Treatment Outcome of DOTS Plus Therapy of MDR-TB Patients at District Tuberculosis Centre

Dr. Meghavi S. Bhapal, Dr. Dharitri D. Thakar, Dr. Harshit G.N, Dr. Ketan Kumar Patel

Background: Expensive and toxic second lines anti tubercular drugs are given under the programme for a longer period of time for the treatment of MDR-TB. However despite being implemented in whole of country, data on programme surveillance is scarce. Adverse drug reactions of second line anti-tubercular drugs affect compliance and thereby treatment outcome. Hence the present study was sought to evaluate the treatment outcome and analyze adverse drug reactions of MDR-TB receiving DOTS plus therapy under programme. Methods: Retrospective study of registered MDR TB cases at district tuberculosis center data regarding demoghaphic profile, ADRs, drug adherence, outcome recorded and analysed. Results: Majority of ADR were Gastrointestinal (46.36 %) followed by generalized weakness (20 %), joint pain (11.81 %), psychological (6.36 %) and others. patients had favorable outcome, amongst them 44 patient were cured and 5 completed treatment. 32 patients had unfavorable outcome, amongst them 19 patients died, 9 became defaulter, 3 became failure to therapy, 1 shifted to bedaquiline based regimen. Conclusions: Cure rate was higher in MDR-TB cases with ADRS than MDR-TB cases without ADR and poor treatment adherence have unfavourable outcome. Objectives: 1) To Study Adverse drug reactions in MDR TB cases. 2) To evaluate and analyze outcome in MDR TB patients.

Keywords: AKT-anti koch treatment, MDR-TB -multidrug resistant tuberculosis, DOTS- directly observed treatment, short course, PMDT- programmatic management of drug resistant TB

Edition: Volume 9 Issue 4, April 2020

Pages: 1775 - 1777


How to Cite this Article?

Dr. Meghavi S. Bhapal, Dr. Dharitri D. Thakar, Dr. Harshit G.N, Dr. Ketan Kumar Patel, "Analysis of Adverse Drug Reactions and Treatment Outcome of DOTS Plus Therapy of MDR-TB Patients at District Tuberculosis Centre", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR20424184815, Volume 9 Issue 4, April 2020, 1775 - 1777

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