Prophylactic Action of Flaxseed Oil against Cyclophosphamide Induced Oxidative Stress in Mice Liver
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064


Amazon Sale


Research Paper | Zoology | India | Volume 9 Issue 4, April 2020

Prophylactic Action of Flaxseed Oil against Cyclophosphamide Induced Oxidative Stress in Mice Liver

Dr. Brij Mohan Singh

The study has been investigated that liver responsible for the detoxification of damaging electrophiles generated during oxidative stress in mammals. Although liver is enriched with endogenous antioxidants, but exogenous antioxidants are more helpful to detoxify toxicity generated by prooxidants. Author found decreased LDL activity in cyclophosphamide (CP) administered mice (90.36 %) and further increase in flaxseed supplementation group (131.51 %) indicating the protective mechanism of lignan component of the flaxseed oil. Similarly, significant increase were found in HDL, Cholesterol, triglycerides activities after CP administration were increased by 104.07 %, 108.84 % and 185.78 % in comparison to control group (32.90 ± 0.34, 14.70 ± 0.41 and 12.80 ± 0.80 µg/ml) and further increased in flaxseed treated mice by 140.18 %, 155.78 % and 400.46 % respectively in comparison to control group of mice. There was also a remarkable elevation in the serum protein markers TNF-α, ALP, ALT, and AST. They were increased by 202.10 %, 254.95 %, 604.08 % and 172.75 % in CP administered group in comparison to control group and further increased by 241.68 %, 492.48 %, 366.78 % and 142.29 % in flaxseed supplemented group of mice. These pathological and biochemical changes correlated well with the altered enzyme activities. The results indicate the anti-oxidative properties of flaxseed oil which showed its prophylactic property against the cyclophosphamide-induced biochemical alterations in mice liver.

Keywords: Cyclophosphamide, prooxidants, oxidative stress, flaxseed oil

Edition: Volume 9 Issue 4, April 2020

Pages: 1709 - 1713

Share this Article

How to Cite this Article?

Dr. Brij Mohan Singh, "Prophylactic Action of Flaxseed Oil against Cyclophosphamide Induced Oxidative Stress in Mice Liver", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR20423102445, Volume 9 Issue 4, April 2020, 1709 - 1713

74 PDF Views | 42 PDF Downloads

Download Article PDF

Click below to Watch Video Lecture of Above Article

Share this Video Lecture

Amazon Sale


Similar Articles with Keyword 'oxidative stress'

Research Paper, Zoology, India, Volume 9 Issue 4, April 2020

Pages: 1709 - 1713

Prophylactic Action of Flaxseed Oil against Cyclophosphamide Induced Oxidative Stress in Mice Liver

Dr. Brij Mohan Singh

Share this Article

Research Paper, Zoology, India, Volume 3 Issue 9, September 2014

Pages: 1564 - 1567

Effects of Acute and Chronic Lead Exposure on Kidney Lipid Peroxidation and Antioxidant Enzyme Activities in BALB-C Mice (Mus Musculus)

Sushma Sharma, Balbinder Singh

Share this Article

Research Paper, Zoology, India, Volume 4 Issue 9, September 2015

Pages: 881 - 884

Antioxidant Activity of Root of Achyranthes Aspera and its Comparison with Melatonin in Recovery of Oxidative Stress

Nisreen Husain, Anil Kumar

Share this Article

Research Paper, Zoology, India, Volume 6 Issue 12, December 2017

Pages: 656 - 661

Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle

Sushma Sharma, Anupam Pundir

Share this Article

Research Paper, Zoology, India, Volume 5 Issue 9, September 2016

Pages: 765 - 767

Analysis of Oxidative Stress Responses in Copper Exposed Catla catla

Gutha Rajasekar, Dr. C Venkatakrishnaiah

Share this Article
Top