Research Paper | Nanotechnology | India | Volume 9 Issue 4, April 2020
Development and Evaluation of Nefidipine Loaded Nanostructured Lipid Carriers (NLCs) For Bioavailability Enhancement
Abstract: Nanostructured Lipid Carriers (NLCs) are new generation of lipid Nanoparticle system, which have showed various advantages over conventional Solid lipid nanoparticles as drug carrier, such as enhanced drug incorporation and release properties. NLCs of Nefidipine were prepared and investigated to estimate the potential of NLCs as an oral drug-delivery system. In this work, solvent injection technique was used to formulate Nefidipine–loaded NLCs. The Nefidipine loaded NLCs showed smooth surface with spherical morphology under scanning electron microscope (SEM) and transmission electron microscope (TEM) analysis. The higher encapsulation efficiency observed was 90.65±0.5 %. In In-Vitro release study, Nefidipine loaded NLCs exhibited a sustained release profile of Nefidipine and no burst release was observed. The oral bioavailability study was performed by using Wistar Albino rats. The relative bioavailability of Nefidipine loaded NLCs was found to be 3.9. In conclusion, the NLC formulation significantly enhanced the oral bioavailability of Nefidipine and revealed a positive aspect for oral delivery of poorly water soluble drugs.
Keywords: Nefidipine, NLCs, Characterization, In Vitro Drug Release, In Vivo Drug Release
Edition: Volume 9 Issue 4, April 2020,
Pages: 1388 - 1394
How to Cite this Article?
Kush Anuradha, "Development and Evaluation of Nefidipine Loaded Nanostructured Lipid Carriers (NLCs) For Bioavailability Enhancement", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR20421221127, Volume 9 Issue 4, April 2020, 1388 - 1394, #ijsrnet
How to Share this Article?
Similar Articles with Keyword 'Characterization'
Review and Synthesis of Silver Nanoparticles, Characterization and Application
Formulation and Characterization of Nifedipine loaded Nanostructured Lipid Carriers coated with Fenugreek Seed Polysaccharide
Dr. S. C. Arora | Anuradha Kush | Chahat Singla | Renu Rani