International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




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Survey Paper | Microbiology | India | Volume 9 Issue 4, April 2020


Comparative Study of Japanese Encephalitis, Live Attenuated Vaccine Potency by CCID50 and PFU Method

Sood Seema | Bhardwaj Arun | Tandon Shweta


Abstract: Japanese Encephalitis, live attenuated vaccine is a cell culture derived (Primary Hamster Kidney), live attenuated vaccine based on the SA 14-14-2 strain manufactured by China and is imported to India. The potency of a live vaccine is typically expressed in terms of the number of infectious unit of viruses contained in human doses using a specified tissue culture substrate. Both BHK-21 cell line as well as vero cell line shows good susceptibility for JE Virus. WHO recommends the use of BHK-21 cell line or any other cell line acceptable to the National Control Authority. In the present study the potency of the JE vaccine was performed by CCID50 & PFU method using Vero cell line.


Keywords: CCID50, Vero cell line, BHK-21 cell line, Cytopathic effect, PFU, Vaccines


Edition: Volume 9 Issue 4, April 2020,


Pages: 969 - 976

Comparative Study of Japanese Encephalitis, Live Attenuated Vaccine Potency by CCID50 and PFU Method


How to Cite this Article?

Sood Seema, Bhardwaj Arun, Tandon Shweta, "Comparative Study of Japanese Encephalitis, Live Attenuated Vaccine Potency by CCID50 and PFU Method", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR20415151936, Volume 9 Issue 4, April 2020, 969 - 976, #ijsrnet

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