International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 163

Research Paper | Pharmacy | India | Volume 9 Issue 4, April 2020


Development and Evaluation of Bilayer Tablets of Losartan Potassium

Shweta Nagpurkar, Rushikesh Rayate


Abstract: The aim of present study is to prepare bilayer tablets of Losartan Potassium with an immediate release and a controlled release layer. The immediate layer was prepared using super disintegrant sodium starch glycolate and controlled release layer is formulated with polymer guar-gum and HPMC K15M, individually in different concentrations and in combinations. The values of pre-compression parameters evaluated were within prescribed limits. (Angle of repose 17.66-26.10, Carrs index 18.05-20.17 % and hausners ratio of 1.19-1.29 indicated good flow property). Post compression parameters such as hardness were found to be 5.46 to 7.21 kg/cm2 sufficient enough to withstand the mechanical stress condition while handling. In all the formulations, the friability value is less 1 % and meets the Indian Pharmacopoeial limits. The percentage drug content of all the tablets was found to be almost are nearer to 100 %, swelling index of matrix tablets were directly proportional to the concentration of the polymer. Formulation (F5) containing combination of guar-gum and HPMC K15M showed better swelling index than that of other formulation. Invitro drug release from the controlled release layer increased with an increase in the polymer concentration because of increase in the thickness of the layer, which retarded drug diffusion out of tablets. Formulation (F5) containing combination of guar-gum and HPMC k15M in equal proportions showed the drug release up to 24hrs. Kinetic release studies of optimized formulation F5 showed zero order release.


Keywords: immediate release, controlled release, polymers, bilayer tablet


Edition: Volume 9 Issue 4, April 2020,


Pages: 145 - 148


How to Cite this Article?

Shweta Nagpurkar, Rushikesh Rayate, "Development and Evaluation of Bilayer Tablets of Losartan Potassium", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR20402130431, Volume 9 Issue 4, April 2020, 145 - 148

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'polymers'

Downloads: 36

Review Papers, Pharmacy, India, Volume 10 Issue 4, April 2021

Pages: 107 - 109

An Overview on Buccal Patches

Vasireddy Praveen

Share this Article

Downloads: 39

Research Paper, Pharmacy, India, Volume 10 Issue 2, February 2021

Pages: 1205 - 1209

Purification, Characterization and Evaluation of Babool Gum as Pharmaceutical Excipients

Vandana Chaudhary, Ravi Kumar Patel, Rishabha Malviya

Share this Article

Similar Articles with Keyword 'release'

Downloads: 1 | Monthly Hits: ⮙1

Student Project, Pharmacy, India, Volume 10 Issue 8, August 2021

Pages: 504 - 508

Formulation Development and Invitro Evaluation of Rosuvastatin Porous Tablets by Using Sublimating Technique

Asim Mohammed

Share this Article

Downloads: 31

Research Paper, Pharmacy, India, Volume 10 Issue 2, February 2021

Pages: 371 - 374

Evaluation of Anti-Pyretic Potential of Indigofera tinctoria using Brewers Yeast induced Pyrexia in Albino Rats

Shubham Bhargava, Yogesh Sharma

Share this Article

Similar Articles with Keyword 'controlled'

Downloads: 133 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Pharmacy, India, Volume 9 Issue 6, June 2020

Pages: 1233 - 1236

Evaluation of Antiepileptic Potential and Muscle Relaxant Activity of Solanum Lycopersicum Leaves in Rodents

Suneel Kumar, Lakhan

Share this Article

Downloads: 56

Research Paper, Pharmacy, India, Volume 9 Issue 11, November 2020

Pages: 1389 - 1394

Sustained Release Oral Dosage Form

Krishan Kant, Archana Rautela

Share this Article
Top