International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064

Research Paper | Hematology Science | Indonesia | Volume 9 Issue 3, March 2020

IgG Kappa Monoclonal Gammopathy Presenting As Constipation: A Case Report

Dian Daniella, Janto Simkoputera

BACKGROUND Monoclonal gammopathies reflect conditions in which abnormal amounts of immunoglobulins are produced by a clone that developed from a single pro-B germ cell. Monoclonal gammopathies may reflect a disease process, such us multiple myeloma. These diseases may be difficult to diagnose because they affect many tissues and exhibit nonspecific symptoms. OBJECTIVE To present a case of monoclonal gammopathy with constipation as one of the manifestation. CASE ILLUSTRATION A 58 years old male was admitted to the hospital due to constipation and abdominal pain for 10 days, fatigue, weight loss and back pain. Blood test showed anemia, leucopenia, thrombocytopenia, markedly high ESR and hypercalcemia. Serum protein electrophoresis showed monoclonal increased in β 2 globulin and suggestive of monoclonal gammopathy. Blood and urine immunofixation showed monoclonal gammopathy IgG kappa. Magnetic resonance imaging (MRI) of lumbal showed compression fracture of 12th vertebrae thoracal to 5th lumbal vertebrae with bulging disc. Bone mass density showed osteoporosis. Based on the result, patient was suspected to have multiple myeloma, but due to refusal of the patient, further evaluation such as bone marrow biopsy was not done. DISCUSSION Constipation may be overlooked as one of the symptoms of monoclonal gammopathy. Upper lumbar vertebra is linked to large bowel movement, and although the sensoric and motoric examination of the patient is normal, but possibly due to compression fracture and bulging disc in lumbar leads to constipation. CONCLUSION It suggested that on practical basis diagnosis of MG should be considered in elderly patients presenting with colitis.

Keywords: monoclonal gammopathy, immunoglobulin, constipation, multiple myeloma

Edition: Volume 9 Issue 3, March 2020

Pages: 1205 - 1207


How to Cite this Article?

Dian Daniella, Janto Simkoputera, "IgG Kappa Monoclonal Gammopathy Presenting As Constipation: A Case Report", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR20321101247, Volume 9 Issue 3, March 2020, 1205 - 1207

41 PDF Views | 37 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'multiple myeloma'

Review Papers, Hematology Science, Macedonia, Volume 4 Issue 11, November 2015

Pages: 1403 - 1406

Is There Improvement in the Care for Patients With Multiple Myeloma?

Svetlana Stankovikj, Kata Martinova, Vera Stankovikj

Share this article

Research Paper, Hematology Science, Saudi Arabia, Volume 6 Issue 2, February 2017

Pages: 165 - 169

The Outcome of Autologous Stem Cell Transplantation: A Single Center Early Experience

Ahmed S. Alaskar; Khaled Alabduljabbar; Abdulellah Aladel; Sultan Aleshaiwi; Maissa Saade; Mohsen Alzahrani; Ayman Alhejazi; Khadeja Ahmed; Dunia Jawdat

Share this article

Research Paper, Hematology Science, Indonesia, Volume 9 Issue 3, March 2020

Pages: 1205 - 1207

IgG Kappa Monoclonal Gammopathy Presenting As Constipation: A Case Report

Dian Daniella, Janto Simkoputera

Share this article

Top