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Research Paper | Pharmaceutical Science | India | Volume 9 Issue 3, March 2020
Development and Validation of UV-Vis Spectroscopy Method for the Determination of Ivabradine Hydrochloride and Metoprolol Succinate in Tablet Dosage Form
S. L Kore | Dr. T. M. Kalyankar
Abstract: A simple, rapid and specific UV spectroscopic method with good sensitivity was developed and validated for the simultaneous determination of Ivabradine hydrochloride and Metoprolol Succinate in combined pharmaceutical dosage form. In distilled water the λ max of Ivabradine hydrochloride and Metoprolol Succinate were fixed as 286.4 and 224 nm respectively using a Shimadzu UV-Visible spectrophotometer. In this proposed method both drugs obeyed linearity within the concentration range of 1-5 µg/ml and 5-25 µg/ml for Ivabradine hydrochloride and Metoprolol Succinate respectively. The low RSD values indicate good precision and high recovery values indicate accuracy of the proposed method. The proposed method has been applied to the determination of drugs in commercial formulations. Assay results were in good agreement with label claim. The method was validated as per ICH guidelines. The developed method was simple, accurate, precise, specific, sensitive and reproducible which can be efficiently and easily applied to pharmaceutical dosage forms.
Keywords: Ivabradine Hydrochloride, Metoprolol Succinate, simultaneous estimation, validation distilled water, UV spectroscopy
Edition: Volume 9 Issue 3, March 2020,
Pages: 1475 - 1482
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