Views: 209 , Downloads: 175 | CTR: 84 % | Weekly Popularity: ⮙6
Research Paper | Medicine Science | Indonesia | Volume 9 Issue 3, March 2020
Breast Cancer Incidence in Diabetes Mellitus Patients on Insulin Glargine Compared with Human Neutral Protamine Hagedorn Insulin Treatment
Noviana Joenputri, Nia Novianti Siregar
Introduction: Observational studies evaluating the association between long-acting insulins and breast cancer incidence is limited. We conducted a systematic review to compare the incidence of breast cancer between diabetes mellitus (DM) patients on long-acting insulin treatment. Methodology: We systematically searched the literatures from MEDLINE, Science Direct and PROQUEST from 2008 to 2018 to identify all observational studies evaluating the relationship between use of insulin glargine and human Neutral Protamine Hagedorn (NPH) insulin to breast cancer incidence among patients with type-1 and/or type-2 diabetes mellitus (DM) aged ≥ 18 years old. The methodological aspects such as residual confounding and duration of follow-up were assessed. Results: A total of four cohort studies met our inclusion criteria. Follow-up duration ranged from 0.9 to 3.3 years. Two studies showed the use of insulin glargine was associated with an increased risk of breast cancer in comparison with human NPH insulin and two other studies found no evidence of breast cancer. All of these studies had a short follow-up duration and were not able to examine residual confounding. Conclusion: We found limited support for association of glargine use with increased breast cancer risk compared to human NPH insulin due to the methodological issues. Further studies with better methodological aspects are needed to explain the difference of breast cancer incidence between those treatments.
Keywords: diabetes mellitus, insulin analog, breast cancer
Edition: Volume 9 Issue 3, March 2020
Pages: 757 - 759
How to Cite this Article?
Noviana Joenputri, Nia Novianti Siregar, "Breast Cancer Incidence in Diabetes Mellitus Patients on Insulin Glargine Compared with Human Neutral Protamine Hagedorn Insulin Treatment", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR20314094229, Volume 9 Issue 3, March 2020, 757 - 759
209 PDF Views | 175 PDF Downloads
Similar Articles with Keyword 'diabetes mellitus'
Risk Factors in Heart Attack
Edi Smajlaj, Sabit Brokaj
Drug Adherence among Diabetic and Hypertensive Patients in Association with Demographic and Healthy Behavior
Jamal Kareem Shakor, MPH, Saleem Saaed Qader, MBChB, MD, MSc, MPH, PhD
The Great Masquerader Complete Heart Block (CHB) With Crusader Hyperkalemia in an Elderly: The Lessons to Reckon
Raghava Sharma, Arjun R
Study of Insulin Secretory Response after Oral Glucose Load in Hypertensive Subjects
Anuradha K., Dr. Ranjana Mathur, Dr. Sadhna Sood, Rohitash K
The Efficacy of Pharmacological Intervention in a Subset of Hyperglycemic Pakistani Population
Adeel Ahmed Shamim, Nayla Ahmed, Asifa Alia, Najmul Islam, Bushra Chaudhry
Similar Articles with Keyword 'breast cancer'
Baseline Needs Assessment for Breast Cancer Awareness and Management among Paramedical Health Care Providers in Iraq
Nada A.S. Alwan; Wafa' M. Alattar; Nawar Al Mallah; Thamira K. Hassoun
Baseline Needs Assessment for Breast Cancer Awareness among Patients in Iraq
Nada A.S. Alwan; Wafa' M. Al-Attar; Nawar Al Mallah
Albanian Doctors Extended Knowledge and Restricted Resources in Management of Breast Cancers High Risk Women
Albana SHAHINI PhD, Erinda KOSTURI MD
Breast Cancer Screening in Relation to Access Barriers to Health Care System
Bissan Isamil Abu-Shammala, Yehia Abed
Effectiveness of Planned Teaching Program (PTP) on Breast Cancer among Working Women at Selected Colleges in Haridwar, Uttrakhand
Ruchi RN RM