International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 109

Case Studies | Medicine | Portugal | Volume 9 Issue 2, February 2020


A Defying Case of Progressive Multifocal Leukoencephalopathy

Joao Oliverio Ribeiro, Joao Pinto Machado, Sara Macedo, Eurico Oliveira


Abstract: Progressive Multifocal Leukoencephalopathy is a diffuse demyelinating disease of the central nervous system, caused by infection by the JC virus, usually associated with immunosuppression. The authors present the case of a 78 years old male, that was brought to the emergency department due to a confusional state. On the emergency department a Brain Computed Tomography was performed, revealing Multiple cortical-subcortical and deep focal hypodensity areas in both hemysferes, associated with dimming of the grooves, of unknown nature, likely secondary. The patient was admitted and a Brain Magnetic Resonance Image was performed, and confirmed the previous results, even though it didn’t exclude the possibility of a demyelinating disease. Considering the likelihood of a Lymphoma, corthicoids where initiated, but failed to improve the Brain lesions, as confirmed by a second Brain Magnetic Resonance. The clinical status of the patient began to deteriorate, and the patient started to become lethargic and with dysphonia. A lumbar puncture was performed and found no neoplasic cells. Facing the images and fast evolution of the disease, the diagnosis of Progressive Multifocal Leukoencephalopathy was assumed.


Keywords: Progressive Multifocal Leukoencephalopathy, Brain lesions, Confusional State


Edition: Volume 9 Issue 2, February 2020,


Pages: 934 - 936


How to Cite this Article?

Joao Oliverio Ribeiro, Joao Pinto Machado, Sara Macedo, Eurico Oliveira, "A Defying Case of Progressive Multifocal Leukoencephalopathy", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR20214172818, Volume 9 Issue 2, February 2020, 934 - 936

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