International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 47 | Monthly Hits: ⮙1

Research Paper | Anaesthesiology | India | Volume 10 Issue 3, March 2021


Oral Clonidine vs Oral Gabapentin for Obtunding Hemodynamic Response to Laryngoscopy and Tracheal Intubation

Dr. Aravinthan Mamallan, Dr. U. G. Thirumaaran


Abstract: Introduction: The sequence of induction of anaesthesia, laryngoscopy and tracheal intubation are highly noxious stimuli associated with marked haemodynamic changes consisting of increase in circulating catecholamines and autonomic reflex activity which involves activation of adrenocortical system. There is an increase in myocardial oxygen demand and dysrhythmias may occur as well. These changes are transient in nature and do not affect healthy individuals however in patients with co morbidities like hypertension, raised intracranial pressure or coronary artery disease. The cardiovascular response is also directly related to the force and duration of laryngoscopy. Both Clonidine, an 2 adrenergic agonist and gabapentin which is a GABA-B receptors agonist causes obtunding of hemodynamic response during laryngoscopy and endotracheal intubation. Aim: The aim of conducting this study was to compare the effects of 100mcg oral Clonidine given 90 min prior to time of surgery with 300mg oral gabapentin given 90 min before surgery in blunting the haemodynamic response to laryngoscopy and intubation. Methodology: A prospective randomized study was done in 60 patients undergoing elective surgeries general anaesthesia in Meenakshi medical college hospital and research institute was selected randomly and the patients were randomly split into two groups of 30 each. One group C received 100mcg of orral clonidine and the other group G received 300 mg of Gabapentin orally 90 minutes before surgery. ECG monitoring, systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP) with noninvasive monitoring and pulse oximetry (SpO2) and ETCO2 monitoring was done and recorded after premedication, after induction, before and during intubation at different time intervals (T0, T1, T3, T5 T10 and T15 minutes). Other adverse effects of this oral premedication with 100mcg Clonidine and 300mg Gabapentin like bradycardia, hypotension, sedation and dryness of mouth were recorded post operatively also. Result: In both group the heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) were increased atT0, T1, T3, T5 and T15. The 1 minute post induction values of SBP, DBP, MAP were significantly less in Clonidine group (P<0.001) and significance persisted upto 5 minutes. Increase in HR was less in Clonidine group than in the Gabapentin group. Conclusion: Premedication with oral Clonidine 100mcg 90 minutes before laryngoscopy and intubation superior to oral gabapentin 300mg in obtunding the hemodynamic response to endotracheal intubation and laryngoscopy.


Keywords: 100mcg oral Clonidine, 300mg oral Gabapentin, direct laryngoscopy, endotracheal intubation, attenuation of hemodynamic response, heart rate systolic blood pressure, diastolic blood pressure, mean arte


Edition: Volume 10 Issue 3, March 2021,


Pages: 232 - 245


How to Cite this Article?

Dr. Aravinthan Mamallan, Dr. U. G. Thirumaaran, "Oral Clonidine vs Oral Gabapentin for Obtunding Hemodynamic Response to Laryngoscopy and Tracheal Intubation", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SR201117230827, Volume 10 Issue 3, March 2021, 232 - 245

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'endotracheal intubation'

Downloads: 77

Informative Article, Anaesthesiology, India, Volume 9 Issue 8, August 2020

Pages: 914 - 915

Routine use of Nasopharyngeal Airway Enhances the Quality of a Fiberoptic / Videobronchoscopic Intubation

Dr. T. Chandana Krishna, Dr. B. Jeevitha, Dr. C. G. Raghuram

Share this Article

Downloads: 85

Comparative Studies, Anaesthesiology, India, Volume 9 Issue 8, August 2020

Pages: 743 - 746

To Evaluate the Efficacy of Oral Clonidine to Attenuate the Haemodynamic Pressor Responses Associated with Laryngoscopy and Endotracheal Intubation in Controlled Hypertensive Patients

Dr Shekhar A Khandare, Dr Noopur D Singh

Share this Article

Similar Articles with Keyword 'mean arte'

Downloads: 23

Research Paper, Anaesthesiology, Egypt, Volume 10 Issue 3, March 2021

Pages: 1567 - 1572

Low Dose Combined Spinal-Epidural Anesthesia Versus Conventional Epidural Anesthesia for Elective Cesarean Section in Severe Preeclampsia

Mamdouh E. Lotffy, Ayman A. Radi, Dr. Nevine M. Soliman, Dr. Khaled M. Gaballah, Amir R. Youssef

Share this Article

Downloads: 100

Research Paper, Anaesthesiology, India, Volume 9 Issue 2, February 2020

Pages: 1017 - 1019

Comparison of Haemodynamic Response to Tracheal Intubation Using Propofol versus Etomidate

Dr. Rekha Meena, Dr. Narendra Singh Choudhary

Share this Article

Similar Articles with Keyword 'oral'

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 7, July 2021

Pages: 476 - 482

An Observational Study Comparing Prophylactic Pre - Operative Gabapentin Vs Granisetron for Prevention of Post Operative Nausea and Vomiting in Laparoscopic Abdominal Surgeries

Dr. Rahul Chaudhary, Dr. Chaitri Shah

Share this Article

Downloads: 17

Case Studies, Anaesthesiology, India, Volume 10 Issue 3, March 2021

Pages: 1244 - 1246

Lymphangioma of Tongue: A Case Report

Dr. Garima Anant, Dr. Ankita Suri

Share this Article

Similar Articles with Keyword 'Clonidine'

Downloads: 1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 744 - 749

Comparative Study of the Intravenously Administered Dexmedetomidine and Clonidine on Attenuation of Haemodynamic Responses to Pneumoperitoneum during Laparoscopic Cholecystectomy

Ashima Gupta, Arpit Singhal, C.K.Vyas

Share this Article

Downloads: 24

Research Paper, Anaesthesiology, India, Volume 10 Issue 4, April 2021

Pages: 667 - 673

Efficacy of Intravenousalpha2 Agonists / Opioids to Atenuate Shivering in Parturiants Undergoing Elective LSCS under Intrathecal Bupivacaine

Dr. Manisha Kapdi, Dr. Aishwariya Raj, Dr. Uma Santoki

Share this Article

Similar Articles with Keyword 'direct'

Downloads: 32

Case Studies, Anaesthesiology, India, Volume 10 Issue 1, January 2021

Pages: 1587 - 1594

A Novel Multimodal Treatment for Management of Pain in Rheumatoid Arthritis; A Case Series

Dr. Lakshmi Vas, Dr Priya Buddhadeo, Dr. Varsha Suryawanshi, Dr Anis Kangani

Share this Article

Downloads: 64

Informative Article, Anaesthesiology, India, Volume 9 Issue 7, July 2020

Pages: 1089 - 1091

A Simple, Indirect Rail-Roading Technique of Ryles Tube Insertion in Anesthetised and Unconscious Patients using Easily Available Gadgets in the Operation Theaters

Dr. B. Jeevitha, Dr. C. G. Raghuram, Dr. Y. Murali Prabhakar

Share this Article

Similar Articles with Keyword 'laryngoscopy'

Downloads: 40

Case Studies, Anaesthesiology, India, Volume 10 Issue 3, March 2021

Pages: 1296 - 1297

Adult Bradycardia during Laryngoscopy: A Case Report

Dr. Garima Anant, Dr. Ankita Suri

Share this Article

Downloads: 75

Case Studies, Anaesthesiology, India, Volume 10 Issue 4, April 2021

Pages: 9 - 11

Case Report on Von Recklinghausen Disease - An Array of Challenges for the Anaesthesiologist in the Era of COVID Pandemic

Dr. P. Veena, Dr. Mariam Joan Varghese

Share this Article

Similar Articles with Keyword 'endotracheal'

Downloads: 5 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Case Studies, Anaesthesiology, India, Volume 10 Issue 7, July 2021

Pages: 786 - 788

Torrential Airway Bleed in Acute Liver Failure Patient Posted for Liver Transplant - A Rare Case Report

Srikanth Kadapa

Share this Article

Downloads: 77

Informative Article, Anaesthesiology, India, Volume 9 Issue 8, August 2020

Pages: 914 - 915

Routine use of Nasopharyngeal Airway Enhances the Quality of a Fiberoptic / Videobronchoscopic Intubation

Dr. T. Chandana Krishna, Dr. B. Jeevitha, Dr. C. G. Raghuram

Share this Article

Similar Articles with Keyword 'intubation'

Downloads: 3

Case Studies, Anaesthesiology, India, Volume 10 Issue 4, April 2021

Pages: 1219 - 1221

Spinal Anaesthesia in a Case of Kyphoscoliosis

Dr. Sanjolisoni, Dr. Suresh Panday, Dr. S. P. Chittora

Share this Article

Downloads: 10

Research Paper, Anaesthesiology, India, Volume 10 Issue 4, April 2021

Pages: 741 - 746

Comparison of Nalbuphine / Fentanyl as Opioid Adjuvant to Propofol based TIVA for Laser Surgery of Larynx

Dr. Rupal J. Shah, Dr. Manisha Kapdi, Dr. Vishal Prajapati, Dr Yatri Joshi

Share this Article

Similar Articles with Keyword 'attenuation'

Downloads: 1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 744 - 749

Comparative Study of the Intravenously Administered Dexmedetomidine and Clonidine on Attenuation of Haemodynamic Responses to Pneumoperitoneum during Laparoscopic Cholecystectomy

Ashima Gupta, Arpit Singhal, C.K.Vyas

Share this Article

Downloads: 111

Comparative Studies, Anaesthesiology, India, Volume 6 Issue 6, June 2017

Pages: 2303 - 2307

A Comparative Study of Dexmedetomidine and Esmolol for Attenuation of Haemodynamic Response to Laryngoscopy and Endotracheal Intubation

Dr Veeresh, Dr Lulu Sherif

Share this Article

Similar Articles with Keyword 'hemodynamic'

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima, Dr M. H. Nagrale

Share this Article

Downloads: 3

Case Studies, Anaesthesiology, India, Volume 10 Issue 5, May 2021

Pages: 366 - 368

Combined Sequential Spinal Epidural Anaesthesia in Geriatric with a STOP BANG Score of 6 for Total Knee Replacement Surgery - The Anaesthesiologist Plight

Dr. P Veena, Dr. Hally T

Share this Article

Similar Articles with Keyword 'response'

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 7, July 2021

Pages: 476 - 482

An Observational Study Comparing Prophylactic Pre - Operative Gabapentin Vs Granisetron for Prevention of Post Operative Nausea and Vomiting in Laparoscopic Abdominal Surgeries

Dr. Rahul Chaudhary, Dr. Chaitri Shah

Share this Article

Downloads: 1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 744 - 749

Comparative Study of the Intravenously Administered Dexmedetomidine and Clonidine on Attenuation of Haemodynamic Responses to Pneumoperitoneum during Laparoscopic Cholecystectomy

Ashima Gupta, Arpit Singhal, C.K.Vyas

Share this Article

Similar Articles with Keyword 'heart'

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima, Dr M. H. Nagrale

Share this Article

Downloads: 1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 744 - 749

Comparative Study of the Intravenously Administered Dexmedetomidine and Clonidine on Attenuation of Haemodynamic Responses to Pneumoperitoneum during Laparoscopic Cholecystectomy

Ashima Gupta, Arpit Singhal, C.K.Vyas

Share this Article

Similar Articles with Keyword 'rate'

Downloads: 1

Photo Essay, Anaesthesiology, India, Volume 10 Issue 5, May 2021

Pages: 1158 - 1158

Clinical Image of Boutonniere and Swan Neck Deformity

Dr. P. Veena, Dr. S. Satish

Share this Article

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima, Dr M. H. Nagrale

Share this Article

Similar Articles with Keyword 'systolic'

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 7, July 2021

Pages: 47 - 52

Comparison of Phenylephrine, Ephedrine and Mephentermine for Control of Hypotension following Spinal Anaesthesia for Infra-Umbilical Surgeries

Dr. Shweta Naresh Satia, Dr. Sameer Kulkarni, Dr. Jyoti Kale

Share this Article

Downloads: 100

Research Paper, Anaesthesiology, India, Volume 9 Issue 2, February 2020

Pages: 1017 - 1019

Comparison of Haemodynamic Response to Tracheal Intubation Using Propofol versus Etomidate

Dr. Rekha Meena, Dr. Narendra Singh Choudhary

Share this Article

Similar Articles with Keyword 'blood'

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima, Dr M. H. Nagrale

Share this Article

Downloads: 1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 744 - 749

Comparative Study of the Intravenously Administered Dexmedetomidine and Clonidine on Attenuation of Haemodynamic Responses to Pneumoperitoneum during Laparoscopic Cholecystectomy

Ashima Gupta, Arpit Singhal, C.K.Vyas

Share this Article

Similar Articles with Keyword 'pressure'

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima, Dr M. H. Nagrale

Share this Article

Downloads: 1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 744 - 749

Comparative Study of the Intravenously Administered Dexmedetomidine and Clonidine on Attenuation of Haemodynamic Responses to Pneumoperitoneum during Laparoscopic Cholecystectomy

Ashima Gupta, Arpit Singhal, C.K.Vyas

Share this Article

Similar Articles with Keyword 'diastolic'

Downloads: 33

Research Paper, Anaesthesiology, India, Volume 10 Issue 3, March 2021

Pages: 614 - 618

A Review of the Intra Aortic Balloon Pump Counter Pulsation Device

Dr B Eliya Naik, Dr Chandrasekhar Krishnamurti

Share this Article

Downloads: 111

Comparative Studies, Anaesthesiology, India, Volume 6 Issue 6, June 2017

Pages: 2303 - 2307

A Comparative Study of Dexmedetomidine and Esmolol for Attenuation of Haemodynamic Response to Laryngoscopy and Endotracheal Intubation

Dr Veeresh, Dr Lulu Sherif

Share this Article

Similar Articles with Keyword 'mean'

Downloads: 1 | Monthly Hits: ⮙1

Research Paper, Anaesthesiology, India, Volume 10 Issue 8, August 2021

Pages: 1178 - 1183

Glycemic Variability in Postoperative Major Oncosurgery Patients and its Effect on Patient Outcomes - A Prospective Observational Study

Manidipam Chatterjee, Chandrashish Chakravarty, Tanmoy Das, Saikat Sengupta

Share this Article

Downloads: 21

Research Paper, Anaesthesiology, India, Volume 10 Issue 4, April 2021

Pages: 336 - 339

Evaluation of Hemodynamic Changes and Recovery Time in Patients under Going Laparoscopic Cholecystectomy - A Clinical Comparison between Desflurane and Sevoflurane

Dr. M. Raghu Praveen Kumar, Dr. T. Swathi Priyadarshini

Share this Article

Similar Articles with Keyword 'arte'

Downloads: 5 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Case Studies, Anaesthesiology, India, Volume 10 Issue 7, July 2021

Pages: 786 - 788

Torrential Airway Bleed in Acute Liver Failure Patient Posted for Liver Transplant - A Rare Case Report

Srikanth Kadapa

Share this Article

Downloads: 23

Research Paper, Anaesthesiology, Egypt, Volume 10 Issue 3, March 2021

Pages: 1567 - 1572

Low Dose Combined Spinal-Epidural Anesthesia Versus Conventional Epidural Anesthesia for Elective Cesarean Section in Severe Preeclampsia

Mamdouh E. Lotffy, Ayman A. Radi, Dr. Nevine M. Soliman, Dr. Khaled M. Gaballah, Amir R. Youssef

Share this Article
Top