International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




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Research Paper | Biomedical Sciences | Indonesia | Volume 9 Issue 11, November 2020


Administration of Kakadu Plum Extract (Terminalia ferdinandiana) Cream Prevented the Increase of Tyrosinase Expression and Melanin Amount on Ultraviolet-B Exposed Male Guinea Pigs (Cavia porcellus) Skin

Maulana Setiawan | Ida Sri Iswari [5] | Ni Wayan Winarti [4]


Abstract: Background: Hyperpigmentation causes various impacts such as lack of confidence and decreased productivity. The gold standard of hyperpigmentation treatment is using 4% hydroquinone that leads to ochronosis, a blue black discoloration in the skin. Thus, it is necessary to find a solution to suppress this side effect. Kakadu plum (Terminalia ferdinandiana) has high ascorbic acid levels, ellagic acid and tanin, which act as an anti- hyperpigmentation agent. This study aims to investigate the effectiveness of Kakadu plum extract cream on male guinea pig's skin exposed to UV-B, related to its role as an anti- hyperpigmentation agent. Method: This research was an experimental study with a randomized post-test only control group design. This study used 36 healthy male guinea pigs (Cavia porcellus), local strain, three months old, 300-350 grams in weight. The sample was divided into two groups randomly. The control group was given a placebo cream, and the treatment group was given 0.1% Kakadu cream every day, 20 minutes before and 4 hours after UV-B radiation with radiation of 65 mJ/cm2 6 times for two weeks. Tyrosinase expression was measured using the Tyrosinase Examination Kit with the immunohistochemistry staining method. The amount of melanin was calculated using a histopathological method with Masson-Fontana staining. Results: The results showed that the mean tyrosinase expression in the treatment group was significantly lower than the control group (36.19?4.60% vs.14.99?2.30%; p<0.001). The mean amount of melanin in the treatment group was also significantly lower than the control group (25.93?4.52% vs.4.40?2.50%; p<0.001). Conclusion: Based on this study's results, it can be concluded that kakadu extract (Terminalia ferdinandiana) cream prevented the increase of tyrosinase expression and melanin amount on ultraviolet B exposed male guinea pigs (Cavia porcellus) skin.


Keywords: melanin, tyrosinase expression, Terminalia ferdinandiana, UVB


Edition: Volume 9 Issue 11, November 2020,


Pages: 1045 - 1049


How to Cite this Article?

Maulana Setiawan, Ida Sri Iswari, Ni Wayan Winarti, "Administration of Kakadu Plum Extract (Terminalia ferdinandiana) Cream Prevented the Increase of Tyrosinase Expression and Melanin Amount on Ultraviolet-B Exposed Male Guinea Pigs (Cavia porcellus) Skin", International Journal of Science and Research (IJSR), Volume 9 Issue 11, November 2020, pp. 1045-1049, https://www.ijsr.net/get_abstract.php?paper_id=SR201116161123

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