International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064




Downloads: 71

Research Paper | Medicine | India | Volume 9 Issue 11, November 2020


Clinical Profile of COVID-19 Patients and QT Interval Changes with Drugs used for Empirical Treatment: A Case Series from Eastern India

Dr. Pradip Saha | Dr Avijit Hazra


Abstract: Background Clinical profiling of COVID-19 cases is lacking from the eastern part of India. Also, the risk of QT prolongation with hydroxychloroquine when used empirically, with or without azithromycin, for the treatment of in COVID-19 is a matter of concern in India. We sought to generate a clinical and laboratory profile of confirmed COVID-19 patients and study the issue of QT prolongation. Design Record based case series Methods Study included 55 confirmed COVID-19 patients admitted to a dedicated COVID-19 treatment facility set up in a tertiary care hospital. ECG was recorded at baseline, prior to start of hydroxychloroquine ± azithromycin, and following administration of the drugs for 48 hours. Results Among 55 COVID-19 patients included in the study, 47 (85.5 %) were symptomatic. Patients had mean (standard deviation [SD]) age of 45.8 (17.76) years and 20 (36.37 %) were female. Fever and cough were the predominant symptoms on admission. Lymphopenia with or without leukocytosis were the dominant laboratory findings. The mean (SD) baseline QTc was 398.4 (46.96) ms; after starting of hydroxychloroquine ± azithromycin it was 401.8 (45.23) ms. QTc changes were not significant statistically or clinically. Conclusions The clinical profile of COVID-19 patients seen in this case series is similar to that documented in other studies published till date. The triad of fever-cough-dyspnea are predominant presenting symptoms. Lymphopenia, with or without leukopenia, could be potential laboratory marker. The use of hydroxychloroquine for treatment, with or without azithromycin, did not show significant QTc prolongation at 48 hours.


Keywords: COVID-19, SARS-CoV-2, India, hydroxychloroquine, azithromycin


Edition: Volume 9 Issue 11, November 2020,


Pages: 909 - 914


How to Cite this Article?

Dr. Pradip Saha, Dr Avijit Hazra, "Clinical Profile of COVID-19 Patients and QT Interval Changes with Drugs used for Empirical Treatment: A Case Series from Eastern India", International Journal of Science and Research (IJSR), Volume 9 Issue 11, November 2020, pp. 909-914, https://www.ijsr.net/get_abstract.php?paper_id=SR201110020922

How to Share this Article?






Similar Articles with Keyword 'India'

Downloads: 115 | Weekly Hits: ⮙1 | Monthly Hits: ⮙2

Research Paper, Medicine, India, Volume 9 Issue 8, August 2020

Pages: 430 - 433

Study on Utilization Pattern of Corticosteroids in Dermatology Unit in Jayanagar General Hospital, Bangalore

Mahesh Raj Joshi | Bishal Subedi | Kajal Jha | Raveendranath S | Ramesh M Tambat [2]

Share this Article

Downloads: 0

Research Paper, Medicine, India, Volume 11 Issue 6, June 2022

Pages: 1859 - 1861

A Study of Acute Severe Post-COVID Sequela and Factors Associated with Poor Prognosis in a Tertiary Care Centre in Andhra Pradesh

Dr. Vaddi Vidya Deepak [3] | Dr. Vasudha Maddukuri [2] | Dr. Vinod Vijjeswarapu | Dr. Swapnika Reddy | Dr. Jahnavi Pasila

Share this Article


Top