Phase I/II Randomized Controlled Clinical Trial to Assess Safety and Efficacy of Ozone Therapy via Rectal Insufflation and Minor Auto Haemotherapy as an Adjuvant in Mild to Moderate COVID-19 Subjects
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064


Amazon Sale


Research Paper | Health and Medical Sciences | India | Volume 9 Issue 10, October 2020

Phase I/II Randomized Controlled Clinical Trial to Assess Safety and Efficacy of Ozone Therapy via Rectal Insufflation and Minor Auto Haemotherapy as an Adjuvant in Mild to Moderate COVID-19 Subjects

Mili Shah, Jignasha Captain, Vidyadhar Vaidya, Arvind Kulkarni, Kedar Valsangkar, Gayatri Ganu

Aims: The present study is proposed to evaluate the safety and efficacy of ozone therapy as an adjuvant along with standard treatment in mild to moderate patients of COVID-19. Settings and Design: This was a randomized, controlled clinical trial with 60 subjects in ozone and standard treatment group (1:1). Methods and Material: Adult subjects of age 30 to 60 of both sex with COVID 19 positive RT-PCR result with mild to moderately severe disease were randomly allocated in either standard treatment or ozone treated group. The RT-PCR test was repeated on day 5 and 10 along with the biochemical tests. Statistical analysis used: Negative RT-PCR test was used for calculation of sample size by software SPSS Version 10.0, the sample size derived for 80% confidence interval as 60 completer subjects i.e. 30 in each group. Results and conclusion: 77% subjects from ozone treated group and 53% from standard treatment group were RT-PCR negative. At day 10, 100% from ozone treatment and 70% from standard treatment were RT-PCR negative. There was significant reduction in clinical symptoms like cough and breathlessness in ozone treated subjects. The inflammatory markers like CRP, LDH and ferritin were reduced more in magnitude than standard treatment group indicating anti-inflammatory potential of ozone therapy. All the biochemical markers like liver, lipid and kidney function test for patients with both groups were within normal range throughout the study. Overall Ozone Therapy was found to be safe and effective choice in management of patients presenting mild to moderate COVID 19.

Keywords: Ozone, COVID-19, RT-PCR, CRP, LDH, ferritin

Edition: Volume 9 Issue 10, October 2020

Pages: 861 - 866

Share this Article

How to Cite this Article?

Mili Shah, Jignasha Captain, Vidyadhar Vaidya, Arvind Kulkarni, Kedar Valsangkar, Gayatri Ganu, "Phase I/II Randomized Controlled Clinical Trial to Assess Safety and Efficacy of Ozone Therapy via Rectal Insufflation and Minor Auto Haemotherapy as an Adjuvant in Mild to Moderate COVID-19 Subjects", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR201012110754, Volume 9 Issue 10, October 2020, 861 - 866

8 PDF Views | 8 PDF Downloads

Download Article PDF


Amazon Sale


Similar Articles with Keyword 'COVID-19'

Research Paper, Health and Medical Sciences, India, Volume 9 Issue 10, October 2020

Pages: 861 - 866

Phase I/II Randomized Controlled Clinical Trial to Assess Safety and Efficacy of Ozone Therapy via Rectal Insufflation and Minor Auto Haemotherapy as an Adjuvant in Mild to Moderate COVID-19 Subjects

Mili Shah, Jignasha Captain, Vidyadhar Vaidya, Arvind Kulkarni, Kedar Valsangkar, Gayatri Ganu

Share this Article

Informative Article, Health and Medical Sciences, Albania, Volume 9 Issue 9, September 2020

Pages: 1436 - 1438

Albanian Primary Care Physicians and COVID Pandemic: Reinventing Primary Health Care Service

Erinda Kosturi MD, Aurora Krasniqi R. N.

Share this Article

Case Studies, Health and Medical Sciences, Indonesia, Volume 9 Issue 9, September 2020

Pages: 1372 - 1374

Severe Clinical Manifestation of COVID-19 with Acute Exacerbation of COPD: A Case Report

I Wayan Angga Suamerta Putra, Wayan Wahyu Semara Putra, Ni Made Dwita Yaniswari

Share this Article

Review Papers, Health and Medical Sciences, India, Volume 9 Issue 9, September 2020

Pages: 519 - 523

Review on COVID 19 - Clinical Characterization, Diagnosis, Management and Potential Treatment

Shivani Borse, Swamini Gawali, Prajyot Burande, Karishma Patil

Share this Article

Review Papers, Health and Medical Sciences, India, Volume 9 Issue 5, May 2020

Pages: 1715 - 1717

Mental Health of Health Care Workers during COVID-19: A Review

Riwanka Khlem

Share this Article

Similar Articles with Keyword 'RT-PCR'

Research Paper, Health and Medical Sciences, India, Volume 9 Issue 10, October 2020

Pages: 861 - 866

Phase I/II Randomized Controlled Clinical Trial to Assess Safety and Efficacy of Ozone Therapy via Rectal Insufflation and Minor Auto Haemotherapy as an Adjuvant in Mild to Moderate COVID-19 Subjects

Mili Shah, Jignasha Captain, Vidyadhar Vaidya, Arvind Kulkarni, Kedar Valsangkar, Gayatri Ganu

Share this Article

Case Studies, Health and Medical Sciences, Indonesia, Volume 9 Issue 9, September 2020

Pages: 1372 - 1374

Severe Clinical Manifestation of COVID-19 with Acute Exacerbation of COPD: A Case Report

I Wayan Angga Suamerta Putra, Wayan Wahyu Semara Putra, Ni Made Dwita Yaniswari

Share this Article

Similar Articles with Keyword 'LDH'

Research Paper, Health and Medical Sciences, India, Volume 9 Issue 10, October 2020

Pages: 861 - 866

Phase I/II Randomized Controlled Clinical Trial to Assess Safety and Efficacy of Ozone Therapy via Rectal Insufflation and Minor Auto Haemotherapy as an Adjuvant in Mild to Moderate COVID-19 Subjects

Mili Shah, Jignasha Captain, Vidyadhar Vaidya, Arvind Kulkarni, Kedar Valsangkar, Gayatri Ganu

Share this Article

Informative Article, Health and Medical Sciences, India, Volume 9 Issue 7, July 2020

Pages: 631 - 634

Prenatal Diagnosis in Service of Mankind

Wahied Khawar Balwan, Neelam Saba

Share this Article
Top