Abstract: Dissolution Profile Mucoadhesive Microgranules of Ranitidine HCL using Polymer Combination of Aloe Vera Powder (Aloe vera L.) and Carbopol 934P On AIF and SIF Media with a Line of Identification Approach
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064

Downloads: 86

Research Paper | Pharmaceutical Science | Indonesia | Volume 9 Issue 10, October 2020

Dissolution Profile Mucoadhesive Microgranules of Ranitidine HCL using Polymer Combination of Aloe Vera Powder (Aloe vera L.) and Carbopol 934P On AIF and SIF Media with a Line of Identification Approach

Endang Diyah Ikasari, Intan Martha Cahyani

There are several factors that influence dissolution test in vitro such as dissolution media. The AIF media (Atrial Intestinal Fluid) and the SIF media (Simulated Intestinal Fluid) media are among the media that can be used in the dissolution test. Mucoadhesive microgranule of ranitidine HCl using a combination polymer of aloe vera powder and carbopol 934P that expands maximally at pH 7.8. The purpose of this study was to determine the dissolution profile of mucoadhesive microgranule of ranitidine HCl in AIF (Atrificial Intestinal Fluid) pH 7.8 and SIF (Simulated Intestinal Fluid) pH 7.8 with a line of identification approach. The method of making granules used is wet granulation. Data analysis using Statistic Product and Service Solution (SPSS) 16.0 with T-Test. The test results showed that the dissolution profile of AIF media followed Higuchi model while in SIF media following release model of order 1. Mechanism of release of mucoadhesive microgranule of ranitidine HCl on SIF media was better than AIF media. Media type significantly influence dissolution test.

Keywords: Carbopol 934P, AIF media, SIF media, ranitidine HCl, aloe vera powder

Edition: Volume 9 Issue 10, October 2020

Pages: 447 - 451

Share this Article

How to Cite this Article?

Endang Diyah Ikasari, Intan Martha Cahyani, "Dissolution Profile Mucoadhesive Microgranules of Ranitidine HCL using Polymer Combination of Aloe Vera Powder (Aloe vera L.) and Carbopol 934P On AIF and SIF Media with a Line of Identification Approach", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SR201001090509, Volume 9 Issue 10, October 2020, 447 - 451

Enter Your Email Address


Similar Articles with Keyword 'Carbopol'

Downloads: 115

Research Paper, Pharmaceutical Science, India, Volume 6 Issue 5, May 2017

Pages: 1064 - 1066

Formulation and Evaluation of Herbal Gel Containing Methanolic Extract of Annonasquamosa Leaves

Mayur Mokashi, Manjusha Dole

Share this Article

Downloads: 126

Research Paper, Pharmaceutical Science, India, Volume 7 Issue 5, May 2018

Pages: 1394 - 1396

Formulation and Evaluation of Herbal Gel Containing Extract of Calotropis gigantea Leaves

Ankita V. Paliwal, Manjusha Dole

Share this Article

Similar Articles with Keyword 'media'

Downloads: 2 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Pharmaceutical Science, India, Volume 10 Issue 7, July 2021

Pages: 87 - 90

Formulation of Nanoparticles of Rabeprazole Sodium for the Treatment of Peptic Ulcer

Ravi Kumar, Vishal Dubey

Share this Article

Downloads: 101

Review Papers, Pharmaceutical Science, India, Volume 7 Issue 1, January 2018

Pages: 1480 - 1483

A Brief Review on Monkey Pox Illness

Sukanya K, Swami.P

Share this Article

Similar Articles with Keyword 'SIF'

Downloads: 163

Research Paper, Pharmaceutical Science, India, Volume 6 Issue 5, May 2017

Pages: 2214 - 2218

Drug Utilization Evaluation of Antiepileptic Drugs in a Tertiary Care Hospital

Nethaji Ramalingam, Anuroop Jose, Arun S, Arya Shihab, Devika S, Sudeep Balakrishnan, Babu Ganesan

Share this Article

Downloads: 5 | Weekly Hits: ⮙1 | Monthly Hits: ⮙4

Review Papers, Pharmaceutical Science, India, Volume 10 Issue 7, July 2021

Pages: 24 - 26

Review on Concept of Blood Pressure

Rohit Deshmukh, Sandip Patil, Hitendra Mahajan

Share this Article

Similar Articles with Keyword 'HCl'

Downloads: 106

Research Paper, Pharmaceutical Science, India, Volume 6 Issue 11, November 2017

Pages: 1616 - 1625

Formulation & Evaluation of Fast Dissolving Oral Thin Film of Ropinirole HCl

Dipak P. Savant

Share this Article

Downloads: 117 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Pharmaceutical Science, India, Volume 8 Issue 9, September 2019

Pages: 1527 - 1533

A Study on Formulation and Evaluation of Oral Dispersible Tablets - Propranolol HCL

D. Radhika

Share this Article

Similar Articles with Keyword 'aloe'

Downloads: 111

Review Papers, Pharmaceutical Science, India, Volume 9 Issue 6, June 2020

Pages: 863 - 867

A Brief Review on Sustained Release Tablet of Glimperide by Using Natural and Synthetic Polymer

Sneha Harichandra Salunkhe, Nilesh Bhosale

Share this Article

Downloads: 155

Research Paper, Pharmaceutical Science, Indonesia, Volume 7 Issue 4, April 2018

Pages: 533 - 536

Development of Sheet Mask with an Extract Golden Sea Cucumber (Golden Stichoupus V) and Gel Aloe Vera (Aloe vera L.) for Facial Treatment

Rahmatul Qodriah, Swasono R. Tamat, Siti Umrah Noor

Share this Article

Similar Articles with Keyword 'vera'

Downloads: 121

Informative Article, Pharmaceutical Science, India, Volume 8 Issue 12, December 2019

Pages: 1349 - 1355

Orphan Drugs

Priya Shaju

Share this Article

Downloads: 3

Research Paper, Pharmaceutical Science, India, Volume 10 Issue 6, June 2021

Pages: 1651 - 1656

Design and Identification of Microspheres: A Review

Niketa Yadav, Pallavi Tiwari

Share this Article

Similar Articles with Keyword 'powder'

Downloads: 2 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Pharmaceutical Science, India, Volume 10 Issue 7, July 2021

Pages: 87 - 90

Formulation of Nanoparticles of Rabeprazole Sodium for the Treatment of Peptic Ulcer

Ravi Kumar, Vishal Dubey

Share this Article

Downloads: 3

Research Paper, Pharmaceutical Science, India, Volume 10 Issue 6, June 2021

Pages: 1651 - 1656

Design and Identification of Microspheres: A Review

Niketa Yadav, Pallavi Tiwari

Share this Article
Top