International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 112

Research Paper | Chemistry | India | Volume 3 Issue 9, September 2014


Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design

Piyush Kumar Thakur, Sandhya Patre, Rama Pande


Abstract: Hydroxamic acid provides central functionality in a number of metalloproteinase inhibitors because of its ability to strongly coordinate with metal ions and as such has high relevance for the development of new pharmaceuticals. Hydroxamic acids, the naturally occurring and synthetic products, generally have low toxicities and are of interest for many therapeutic applications. The lipophilicity of a series of hydroxamic acids have been measured experimentally between chloroform-water, octanol-water and chloroform-octanol systems, by the shake-flask method. Measured lipophilicities of compounds obtained are in the range 2.516 to 2.358. The measured Hydrogen Bond Donor (HBD) and Hydrogen Bond Acceptor (HBA) strengths are in the range 0.6239 to 0.7098 and 1.9288 to 2.8292, respectively. This study is designed to assess the correlation between the lipophilicity of the compounds and their biological activity. The results show that these molecules have better chances to arrive at receptor sites. In QSAR where physico-chemical parameters of drugs are correlated with biological activities, lipophilicity plays a major role. A knowledge of these parameters will help in designing the better drug delivery system and more accurately marked pharmaceuticals and pesticides.


Keywords: Hydroxamic acid, partition coefficient, hydrogenbonds, lipophilicity


Edition: Volume 3 Issue 9, September 2014,


Pages: 1545 - 1548


How to Cite this Article?

Piyush Kumar Thakur, Sandhya Patre, Rama Pande, "Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SEP14447, Volume 3 Issue 9, September 2014, 1545 - 1548

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Hydroxamic acid'

Downloads: 2 | Monthly Hits: ⮙1

Research Paper, Chemistry, Sudan, Volume 10 Issue 7, July 2021

Pages: 617 - 620

Spectrophotometric Study of Stability Constants of Fe (III), Co (II) and Cu (II) Complexes of Salicylhydroxamic Acid at Room Temperatures

Leena Salah Ibrahim, Elmugdad Ahmed Ali, Mohammed Sulieman Ali

Share this Article

Downloads: 2 | Monthly Hits: ⮙1

Research Paper, Chemistry, Sudan, Volume 10 Issue 7, July 2021

Pages: 621 - 626

Preparation and Characterization of Salicylhydroxamic acid and its Complexes with Iron (III), Cobalt (II) and Manganese (II)

Leena Salah Ibrahim, Elmugdad Ahmed Ali, Mohammed Sulieman Ali

Share this Article

Similar Articles with Keyword 'partition coefficient'

Downloads: 99

Research Paper, Chemistry, India, Volume 3 Issue 6, June 2014

Pages: 1550 - 1553

Phase Interactions of DL Alanine; hexa-glycine; NH4Cl; NaCl; KCl; NaBr; KBr; and KI in Aqueous Two-Phase Systems of poly (ethylene glycol) 600 + dextranT(40) at 293.15 K

Vijendra P. Singh

Share this Article

Downloads: 122

M.Tech / M.E / PhD Thesis, Chemistry, Saudi Arabia, Volume 6 Issue 11, November 2017

Pages: 968 - 972

Preparation, Characterization and Evaluation of the Extraction Efficiency of Phthalohydroxamic Acid towards Nickel and Cobalt Cations

Dr. Egbal Eltom Bakheet, Dr. Elmugdad Ahmed Ali

Share this Article

Similar Articles with Keyword 'Hydroxamic'

Downloads: 2 | Monthly Hits: ⮙1

Research Paper, Chemistry, Sudan, Volume 10 Issue 7, July 2021

Pages: 617 - 620

Spectrophotometric Study of Stability Constants of Fe (III), Co (II) and Cu (II) Complexes of Salicylhydroxamic Acid at Room Temperatures

Leena Salah Ibrahim, Elmugdad Ahmed Ali, Mohammed Sulieman Ali

Share this Article

Downloads: 2 | Monthly Hits: ⮙1

Research Paper, Chemistry, Sudan, Volume 10 Issue 7, July 2021

Pages: 621 - 626

Preparation and Characterization of Salicylhydroxamic acid and its Complexes with Iron (III), Cobalt (II) and Manganese (II)

Leena Salah Ibrahim, Elmugdad Ahmed Ali, Mohammed Sulieman Ali

Share this Article

Similar Articles with Keyword 'acid'

Downloads: 53

Research Paper, Chemistry, Nigeria, Volume 2 Issue 3, March 2013

Pages: 457 - 459

Selenium Content in some Brands of Bottled Beer Marketed in Makurdi Town Benue State, Nigeria

A. D. Oklo, R. Sha'Ato, K. Asemave, C.Mkurzurum

Share this Article

Downloads: 120 | Monthly Hits: ⮙3

Research Paper, Chemistry, India, Volume 3 Issue 6, June 2014

Pages: 2047 - 2050

Removal of Lead from Aqueous Solution Using Black Liquor - A Pulp Mill Waste

Anuja Agarwal, Babita Kapil

Share this Article

Similar Articles with Keyword 'partition'

Downloads: 99

Research Paper, Chemistry, India, Volume 3 Issue 6, June 2014

Pages: 1550 - 1553

Phase Interactions of DL Alanine; hexa-glycine; NH4Cl; NaCl; KCl; NaBr; KBr; and KI in Aqueous Two-Phase Systems of poly (ethylene glycol) 600 + dextranT(40) at 293.15 K

Vijendra P. Singh

Share this Article

Downloads: 122

M.Tech / M.E / PhD Thesis, Chemistry, Saudi Arabia, Volume 6 Issue 11, November 2017

Pages: 968 - 972

Preparation, Characterization and Evaluation of the Extraction Efficiency of Phthalohydroxamic Acid towards Nickel and Cobalt Cations

Dr. Egbal Eltom Bakheet, Dr. Elmugdad Ahmed Ali

Share this Article

Similar Articles with Keyword 'coefficient'

Downloads: 120 | Monthly Hits: ⮙3

Research Paper, Chemistry, India, Volume 3 Issue 6, June 2014

Pages: 2047 - 2050

Removal of Lead from Aqueous Solution Using Black Liquor - A Pulp Mill Waste

Anuja Agarwal, Babita Kapil

Share this Article

Downloads: 2 | Monthly Hits: ⮙1

Research Paper, Chemistry, India, Volume 10 Issue 11, November 2021

Pages: 660 - 662

Spectrophotometric Method for Analysis of Valasartan

Dr. K. Sandhyarani

Share this Article
Top