International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Research Paper | Chemistry Science | India | Volume 3 Issue 9, September 2014

Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design

Piyush Kumar Thakur, Sandhya Patre, Rama Pande

Hydroxamic acid provides central functionality in a number of metalloproteinase inhibitors because of its ability to strongly coordinate with metal ions and as such has high relevance for the development of new pharmaceuticals. Hydroxamic acids, the naturally occurring and synthetic products, generally have low toxicities and are of interest for many therapeutic applications. The lipophilicity of a series of hydroxamic acids have been measured experimentally between chloroform-water, octanol-water and chloroform-octanol systems, by the shake-flask method. Measured lipophilicities of compounds obtained are in the range 2.516 to 2.358.The measured Hydrogen Bond Donor (HBD) and Hydrogen Bond Acceptor (HBA) strengths are in the range 0.6239 to 0.7098 and 1.9288 to 2.8292, respectively. This study is designed to assess the correlation between the lipophilicity of the compounds and their biological activity. The results show that these molecules have better chances to arrive at receptor sites. In QSAR where physico-chemical parameters of drugs are correlated with biological activities, lipophilicity plays a major role. A knowledge of these parameters will help in designing the better drug delivery system and more accurately marked pharmaceuticals and pesticides.

Keywords: Hydroxamic acid, partition coefficient, hydrogenbonds, lipophilicity

Edition: Volume 3 Issue 9, September 2014

Pages: 1545 - 1548


How to Cite this Article?

Piyush Kumar Thakur, Sandhya Patre, Rama Pande, "Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SEP14447, Volume 3 Issue 9, September 2014, 1545 - 1548

35 PDF Views | 26 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Hydroxamic acid'

Research Paper, Chemistry Science, India, Volume 4 Issue 5, May 2015

Pages: 1017 - 1019

Potentiometric Study of Hydroxamic Acids in Non- Aqueous Media

Piyush Kumar Thakur, Sandhya Patre

Share this article

Research Paper, Chemistry Science, India, Volume 3 Issue 9, September 2014

Pages: 1545 - 1548

Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design

Piyush Kumar Thakur, Sandhya Patre, Rama Pande

Share this article



Similar Articles with Keyword 'partition coefficient'

Research Paper, Chemistry Science, India, Volume 3 Issue 6, June 2014

Pages: 1550 - 1553

Phase Interactions of DL Alanine; hexa-glycine; NH4Cl; NaCl; KCl; NaBr; KBr; and KI in Aqueous Two-Phase Systems of poly (ethylene glycol) 600 + dextranT(40) at 293.15 K

Vijendra P. Singh

Share this article

Research Paper, Chemistry Science, India, Volume 3 Issue 9, September 2014

Pages: 1545 - 1548

Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design

Piyush Kumar Thakur, Sandhya Patre, Rama Pande

Share this article



Similar Articles with Keyword 'lipophilicity'

Review Papers, Chemistry Science, India, Volume 3 Issue 4, April 2014

Pages: 573 - 575

Determination of Hydrophilic-Lipophilic Balance Value

Ashish Gadhave

Share this article

Research Paper, Chemistry Science, India, Volume 3 Issue 9, September 2014

Pages: 1545 - 1548

Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design

Piyush Kumar Thakur, Sandhya Patre, Rama Pande

Share this article
Top

In this paper, we are dealing with Stancu Beta operators V ; n de ned by (1.5). We establish direct and local approximation properties of these operators.