International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Review Papers | Physics Science | Egypt | Volume 3 Issue 9, September 2014

Effect of Radiofrequency Irradiation on Hepatocarcinoma

Hala Moustafa Ahmed, Moustafa Moustafa Ahmed, Amira Hamed Mohamed, Mohamed Sameh Nasr

Hepatocellular Carcinoma (HCC) is one of the most common and dangerous diseases that attacks the human liver, it is considered the fifth cause of death worldwide, in Egypt a high incidence of HCC had been reported, there is a strong association between HCV infection & cirrhosis and HCC. The aim of this study is to study the texture, density and the progress of the hepatocellular carcinoma before and after the treatment, using the modern screening modalities such as computed tomography, ultrasound and laboratory investigations such as tumor marker examinations alpha-fetoprotein, alanine transferees (AFP, ALT) and the temperature induced by the RFA inside the tumor tissue. The basic principle of radiofrequency ablation depends on the effect of temperature induced by the radiofrequency machine which had proved its ability to cause complete ablation of the HCC. So we had used specific mathematical equations to calculate the degree of temperature induced by the radiofrequency wave during the treatment using the available parameter current, watt, impedance of the tumor cells that can be easily monitored during the treatment. This study proved that radiofrequency ablation of hepatocellular carcinoma had a very high effect in destroying the tumor cells and this was monitored by computed tomography, by tumor markers and mathematical calculations.The temperature rise induced by RF during the treatment reaches 100 oC and more and ablation occurs at 4-10 min. At low power temperature at tumor surface varied from 60-225 oC and at high power temperature varied from 140-179 oC. At low power temperature at electrode surface varied from 88-223 oC and at high power temperature varied from 143-278 oC. The total complete necrosis rate after the first session was (87.5 %).The total complete necrosis rate after multiple sessions was 95.8 %.The total complete necrosis rate after multiple sessions was 95.8 %.Mean ALT activity measured before treatment were average of males group (50.16+ 12.8 S.D IU/L), and average of females group (58.37+12 S.D IU/L), mean AST measured before treatment were average of males group (46.9+19.1S.D IU/L), and average of females group (52.8+13.8S.D IU/L).Mean HCV-RNA measured before treatment were average of males group (78.3 + 11.3 S.D copies /ml), and average of females group (84.5 + 6.35 S.D copies /ml). The normal ranges for HCV-RNA in males and females are (>2 x106 copies /ml).Pretreatment CT with contrast shows enhanced tumors. After RF ablation HCC have been replaced by a larger non enhanced necrotic area.

Keywords: Hepatocarcinoma-Image guided-Radiofrequency ablation

Edition: Volume 3 Issue 9, September 2014

Pages: 2258 - 2263


How to Cite this Article?

Hala Moustafa Ahmed, Moustafa Moustafa Ahmed, Amira Hamed Mohamed, Mohamed Sameh Nasr, "Effect of Radiofrequency Irradiation on Hepatocarcinoma", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SEP14330, Volume 3 Issue 9, September 2014, 2258 - 2263

27 PDF Views | 26 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Hepatocarcinoma-Image guided-Radiofrequency ablation'

Review Papers, Physics Science, Egypt, Volume 3 Issue 9, September 2014

Pages: 2258 - 2263

Effect of Radiofrequency Irradiation on Hepatocarcinoma

Hala Moustafa Ahmed, Moustafa Moustafa Ahmed, Amira Hamed Mohamed, Mohamed Sameh Nasr

Share this article

Review Papers, Physics Science, Egypt, Volume 3 Issue 10, October 2014

Pages: 171 - 176

Effect of Radio Frequency Irradiation on Hepatocarcinoma

Hala Moustafa Ahmed. Moustafa Moustafa Ahmed, Amira Hamed Mohamed. Mohamed Sameh Nasr

Share this article
Top