Downloads: 98
Research Paper | Medicine Science | India | Volume 3 Issue 11, November 2014
Comparative Evaluation of Oral Gabapentin and Pregabalin Premedication for Attenuation of Pressor Response to Endotracheal Intubation under General Anaesthesia
Namratha. S. Urs, ShobhaD
Abstract: Purpose: Laryngoscopy and tracheal intubation causes severe noxious stimuli that induce an intense sympathetic hemodynamic response. This study aims to investigate the effect and safety of oral gabapentin and pregabalin in attenuating these responses. Methods: This is a prospective, randomized, double blind, placebo controlled study in which 90 adult ASA I and II patients undergoing elective surgery of both sexes were divided into three groups. Group A received placebo, Group B received oral gabapentin 800mg and Group C received pregabalin 150mg orally. Base line heart rate (HR), mean arterial pressure (MAP) and before induction, after induction, at the time of laryngoscopy and at the end of 0, 1, 3, 5 and 10min were recorded. Sedation score of all the 3 groups were recorded. Results: When compared to gabapentin and pregabalin, there was a significant increase in HR and MAP in control group after laryngoscopy and tracheal intubation. Pregabalin being more sedative than gabapentin is better than gabapentin in suppressing the pressor response. Conclusion: Oral gabapentin and pregabalin is a safe, simple and economical method in attenuating the pressor response to laryngoscopy and tracheal intubation.
Keywords: Gabapentin, Pregabalin, Laryngoscopy, Pressor response, Tracheal intubation
Edition: Volume 3 Issue 11, November 2014,
Pages: 654 - 658
How to Cite this Article?
Namratha. S. Urs, ShobhaD, "Comparative Evaluation of Oral Gabapentin and Pregabalin Premedication for Attenuation of Pressor Response to Endotracheal Intubation under General Anaesthesia", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=OCT14988, Volume 3 Issue 11, November 2014, 654 - 658
How to Share this Article?
Similar Articles with Keyword 'Gabapentin'
Downloads: 115
Comparative Studies, Medicine Science, India, Volume 4 Issue 8, August 2015
Pages: 1735 - 1740Comparing the Effects of Oral Gabapentin and Clonidine on Preoperative Anxiolysis and Attenuation of Stress Response to Endotracheal Intubation
Jay Brijesh S.Yadav, Usha Shukla, S.P. Singh
Downloads: 148
Research Paper, Medicine Science, India, Volume 7 Issue 2, February 2018
Pages: 223 - 225Prophylaxis against Postoperative Nausea and Vomiting in Patients undergoing Laparoscopic Abdominal Surgeries with Gabapentin alone and Gabapentin-Dexamethasone and their Comparison with Ondansetron
Anas Wahab Ansari, Rajiv Gautam, L. S. Mishra
Similar Articles with Keyword 'Laryngoscopy'
Downloads: 101
Case Studies, Medicine Science, Turkey, Volume 3 Issue 11, November 2014
Pages: 906 - 908Difficult Airway Management in an Ankylosing Spondilitis Patient
Esra Mercanoglu Efe, Tolga Yazc, Gltekin Orhan, Aysun Ylmazlar
Downloads: 117
Research Paper, Medicine Science, India, Volume 7 Issue 1, January 2018
Pages: 1989 - 1993Success of Tracheal Intubation under Vision Using the LMA C-Trach, A New Laryngeal Mask Airway: Evaluation in 30 Patients
Dr. Bhavna Soni, Dr. Nikita S. Badmaliya, Dr. Bhavna H. Sojitra, Dr. Pragna Vachharajani
Similar Articles with Keyword 'Tracheal intubation'
Downloads: 111
Research Paper, Medicine Science, India, Volume 6 Issue 5, May 2017
Pages: 1656 - 1659Real Time Point of care Ultrasonography versus Auscultation for the confirmation of Endotracheal versus Bronchial Intubation in Emergency Department
Dr Ganesha BS, Dr Narendra SS, Dr Udaykumar JK, Dr Bharath K, Dr Vijaykumar
Downloads: 115
Comparative Studies, Medicine Science, India, Volume 4 Issue 8, August 2015
Pages: 1735 - 1740Comparing the Effects of Oral Gabapentin and Clonidine on Preoperative Anxiolysis and Attenuation of Stress Response to Endotracheal Intubation
Jay Brijesh S.Yadav, Usha Shukla, S.P. Singh