International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Research Paper | Chemistry Science | Indonesia | Volume 3 Issue 10, October 2014

The Curcuminoids Extract of Curcuma xanthorrhiza RoxB. Loaded Solid Lipid Nanoparticles

Laksmi Ambarsari, Waras Nurcholis, Latifah K Darusman, Muslih Abdul Mujib, Rudi Heryanto

Curcuma xanthorrhiza RoxB. is the medicinal plant that widely used in Indonesian traditional herbal medicine (Jamu). The curcuminoids is well known for its pharmacological properties such as antioxidant, anti-inflammatory, and anti-carcinogenic. The curcuminoids is weakly soluble in water that restrict its bioavailability. This problem could be overcome by incorporated curcuminoid into solid lipid nanoparticles (SLN). The purpose of this study was to produce and characterize curcuminoids extract loaded solid lipid nanoparticles (curcuminoids-SLN) from C. xanthorrhiza. The curcuminoids-SLN was prepared using different composition of curcuminoid extract, surfactant and lipid. It was produced by using homogenization-ultra sonication methods. The particle was characterized for its size, properties and entrapment efficiency. Result showed that the best composition for producing curcuminoids-SLN was palmitic acid: curcuminoids: surfactants with weight ratio 1: 0.5: 1.5 with entrapment efficiency 72.98 %. The particle size was 285.576.7 nm. The FTIR spectral data of curcuminoids-SLN was reflection of raw materials spectrum and XRD measurement showed that crystallinity of curcuminoids-SLN in the good agreement with palmitic acid.

Keywords: curcuma xanthorrhiza, solid lipid nanoparticle, curcuminoids, bioavailability, ultra sonication

Edition: Volume 3 Issue 10, October 2014

Pages: 852 - 856


How to Cite this Article?

Laksmi Ambarsari, Waras Nurcholis, Latifah K Darusman, Muslih Abdul Mujib, Rudi Heryanto, "The Curcuminoids Extract of Curcuma xanthorrhiza RoxB. Loaded Solid Lipid Nanoparticles", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=OCT14261, Volume 3 Issue 10, October 2014, 852 - 856

36 PDF Views | 32 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'curcuminoids'

Research Paper, Chemistry Science, India, Volume 4 Issue 9, September 2015

Pages: 1676 - 1680

Antibacterial and Antifungal Activities of Curcuminoid Analogue with Chloro Substituted Phenyl Ring and the Transition Metal Chelates

Seena Thomachan, S. Sindhu

Share this article

Research Paper, Chemistry Science, Indonesia, Volume 3 Issue 10, October 2014

Pages: 852 - 856

The Curcuminoids Extract of Curcuma xanthorrhiza RoxB. Loaded Solid Lipid Nanoparticles

Laksmi Ambarsari, Waras Nurcholis, Latifah K Darusman, Muslih Abdul Mujib, Rudi Heryanto

Share this article



Similar Articles with Keyword 'bioavailability'

Research Paper, Chemistry Science, Iraq, Volume 6 Issue 2, February 2017

Pages: 1178 - 1183

Estimation of Cortisone Acetate in Pharmaceutical Anti-inflammatory Drugs by HPLC-UV Technique

H. N. K. AL-Salman, Shaker.A.N.AL-Jadaan

Share this article

Research Paper, Chemistry Science, India, Volume 4 Issue 3, March 2015

Pages: 1690 - 1691

Thermal Effects on the Solubility Enhancement of Immiscible Synthetic Drugs through Sodium Dodecyl Sulphate Aqueous Medium

Nariman Firdaus, Dr. S. K. Chatterjee

Share this article

Research Paper, Chemistry Science, Indonesia, Volume 3 Issue 10, October 2014

Pages: 852 - 856

The Curcuminoids Extract of Curcuma xanthorrhiza RoxB. Loaded Solid Lipid Nanoparticles

Laksmi Ambarsari, Waras Nurcholis, Latifah K Darusman, Muslih Abdul Mujib, Rudi Heryanto

Share this article
Top