International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Most Trusted Research Journal Since Year 2012

ISSN: 2319-7064



Research Paper | Biochemistry | India | Volume 3 Issue 10, October 2014

Proteolytic Imbalance in Depression as Potential Pathological Trait of Diseases

Fakhra Amin, Bilqees Bano

Cystatins are the thiol Proteinase inhibitors, present ubiquitously in mammalian body. They prevent unwanted proteolysis and play important role in several diseases. Regulation of cysteine Proteinase and their inhibitors is of utmost importance in diseases like Alzheimer, amlyoid angiopathy and other neurodegenerative disease. Haloperidol is an antipsychotic drug used in the treatment of schizophrenia. In this paper interaction of brain cystatin ( BC) with haloperidol has been studied by U.V absorption and fluorescence spectroscopy to explore the drug induced changes in functional and structural integrity of the brain cystatin. The fluorescence quenching data analysed by stern vomer analyses indicated the presence of static component in the quenching mechanism. The thermodynamic parameters G0 (Free energy change) found to be -39.377 KJ/mol revealed that both hydrogen bonds and hydrophobic interactions played a major role in the binding of Haloperidol with BC. This binding leads to decrease in the activity of cystatin showing its involvement in protease -antiprotease imbalance It may also be taken as the side effect of the drug haloperidol, such studies may be used as a tool for drug designing.

Keywords: Haloperidol, Cystatin, Antidepressant, Neurotransmitter, Purification of Buffalo Brain Cystatin, Thiol Proteinase Inhibitors, depression schizophrenia

Edition: Volume 3 Issue 10, October 2014

Pages: 972 - 976


How to Cite this Article?

Fakhra Amin, Bilqees Bano, "Proteolytic Imbalance in Depression as Potential Pathological Trait of Diseases", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=OCT1414, Volume 3 Issue 10, October 2014, 972 - 976

28 PDF Views | 25 PDF Downloads

Download Article PDF



Similar Articles with Keyword 'Neurotransmitter'

Research Paper, Biochemistry, India, Volume 3 Issue 10, October 2014

Pages: 972 - 976

Proteolytic Imbalance in Depression as Potential Pathological Trait of Diseases

Fakhra Amin, Bilqees Bano

Share this article

Research Paper, Biochemistry, India, Volume 8 Issue 4, April 2019

Pages: 1167 - 1174

Role of Apoptosis in Cadmium Induced Dopaminergic Alterations in Rat Brain

Shraddha Prakash, Chitranshu Pandey

Share this article
Top