International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 115

Research Paper | Medicine Science | Nigeria | Volume 5 Issue 3, March 2016


Superoxide Dismutase and Glutathione Peroxidase Levels in Patients with Long Standing Type 2 Diabetes in Port Harcourt, Rivers State, Nigeria

Ojoye Ngoye Briggs, Holy Brown, Kemzi Elechi-amadi, Ferdinand Ezeiruaku, Nsirim Nduka


Abstract: Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. It is associated with increased oxidative stress. This study evaluates the levels of the antioxidant enzymes superoxide dismutase (SOD) and gluthathione peroxidase (GPx), as a measure of antioxidant status in Type 2 diabetics. A total of 182 subjects were involved in the study, of which 109 were diabetics (Test) and 73 non-diabetics (Controls). The criterion for the classification as a diabetic was based on subjects having glycated haemoglobin (HbA1c) levels 6.5 %. A structured interviewer administered questionnaire was used as an aid in the collection of demographic and lifestyle data from the subjects. HbA1c was estimated quantitatively by immunochemical method. SOD and GPx was measured by the sandwich-enzyme linked immunosorbent assay (ELISA) method. Glucose oxidase method was used for the determination of fasting plasma glucose (FPG). Mean SOD and GPx values in the diabetic subjects were significantly lower (p


Keywords: Diabetes mellitus, Superoxide dismutase, Glutathione peroxidase, Antioxidants, Hyperglycaemia


Edition: Volume 5 Issue 3, March 2016,


Pages: 1282 - 1288


How to Cite this Article?

Ojoye Ngoye Briggs, Holy Brown, Kemzi Elechi-amadi, Ferdinand Ezeiruaku, Nsirim Nduka, "Superoxide Dismutase and Glutathione Peroxidase Levels in Patients with Long Standing Type 2 Diabetes in Port Harcourt, Rivers State, Nigeria", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=NOV162149, Volume 5 Issue 3, March 2016, 1282 - 1288

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Diabetes mellitus'

Downloads: 1

Research Paper, Medicine Science, Albania, Volume 4 Issue 3, March 2015

Pages: 2210 - 2212

Risk Factors in Heart Attack

Edi Smajlaj, Sabit Brokaj

Share this Article

Downloads: 104

Research Paper, Medicine Science, India, Volume 4 Issue 9, September 2015

Pages: 1744 - 1747

Study of Insulin Secretory Response after Oral Glucose Load in Hypertensive Subjects

Anuradha K., Dr. Ranjana Mathur, Dr. Sadhna Sood, Rohitash K

Share this Article

Similar Articles with Keyword 'Superoxide dismutase'

Downloads: 101

Research Paper, Medicine Science, Iraq, Volume 4 Issue 11, November 2015

Pages: 2262 - 2264

Evaluate the Effect of Coenzymeq10 Supplementation on Reducing Oxidative Stress in Patients with Relapsing Remitting Multiple Sclerosis

Mariam Omran Waheed, Haider Al- Tukmagi, Ali Kadhim Kareem

Share this Article

Downloads: 130 | Monthly Hits: ⮙1

Review Papers, Medicine Science, India, Volume 8 Issue 9, September 2019

Pages: 629 - 633

A Review on Inflammatory Bowel Disease and their Treatment

Mojabir Hussen Ansari, Dr. Sheelpriya R. Walde

Share this Article

Similar Articles with Keyword 'Glutathione peroxidase'

Downloads: 133

Research Paper, Medicine Science, Nigeria, Volume 5 Issue 4, April 2016

Pages: 633 - 636

Assessment of Antioxidant Enzymes and Cortisol Levels among HIV Patients on HAART

Brown Holy, Elechi-Amadi, Kemzi Nosike

Share this Article

Downloads: 194

Research Paper, Medicine Science, Congo, Volume 8 Issue 12, December 2019

Pages: 365 - 373

Effect of Probiotic Yogurt Supplementation on Intestinal Inflammation and Oxidative Stress in HIV-Positive Patients on Antiretroviral Therapy: Randomized Controlled Trials in 24 and 48 Weeks

Kasamba Ilunga Eric, Balaka Ekwalanga Michel, Mulumba Kadiebwe David, Kalumba Kambote Athy, Ilunga Nikulu Julian, Lungu Anzwal, Kalenga Mwenze Kayamba Prosper, Malangu Mposhy Emmanuel Prosper

Share this Article

Similar Articles with Keyword 'Antioxidants'

Downloads: 91

Research Paper, Medicine Science, Bulgaria, Volume 4 Issue 7, July 2015

Pages: 1169 - 1171

Contemporary Treatment of Parkinsons Disease

Mancheva-Ganeva Velina, Manchev Lachezar, Ganev Iordan, Manchev Ivan

Share this Article

Downloads: 110

Research Paper, Medicine Science, India, Volume 5 Issue 5, May 2016

Pages: 1123 - 1128

Antioxidant Potential of Selected Medicinal Plants of Trans- Himalayan Region

Suman Tiga, Prabhu Sarangi, Omprakash Chaurasia, Bhuvnesh Kumar

Share this Article

Similar Articles with Keyword 'Diabetes'

Downloads: 1

Research Paper, Medicine Science, Albania, Volume 4 Issue 3, March 2015

Pages: 2210 - 2212

Risk Factors in Heart Attack

Edi Smajlaj, Sabit Brokaj

Share this Article

Downloads: 37

Research Paper, Medicine Science, Saudi Arabia, Volume 6 Issue 1, January 2017

Pages: 2450 - 2458

Awareness on Diabetes Complications and Protective Measures in Makkah Region among Known Diabetic Patients: A Cross-Sectional Survey

Anoud R. Omer; Abdullah A. Alghamdi; Rakan A. AlYamani; Salman H. Alqurash; Abdulaziz A. Alshikh; Roa'a A. Alshaik; Mohamed E. Salih; Anees A Sindi

Share this Article

Similar Articles with Keyword 'mellitus'

Downloads: 1

Research Paper, Medicine Science, Albania, Volume 4 Issue 3, March 2015

Pages: 2210 - 2212

Risk Factors in Heart Attack

Edi Smajlaj, Sabit Brokaj

Share this Article

Downloads: 104

Research Paper, Medicine Science, India, Volume 4 Issue 9, September 2015

Pages: 1744 - 1747

Study of Insulin Secretory Response after Oral Glucose Load in Hypertensive Subjects

Anuradha K., Dr. Ranjana Mathur, Dr. Sadhna Sood, Rohitash K

Share this Article

Similar Articles with Keyword 'Superoxide'

Downloads: 101

Research Paper, Medicine Science, Iraq, Volume 4 Issue 11, November 2015

Pages: 2262 - 2264

Evaluate the Effect of Coenzymeq10 Supplementation on Reducing Oxidative Stress in Patients with Relapsing Remitting Multiple Sclerosis

Mariam Omran Waheed, Haider Al- Tukmagi, Ali Kadhim Kareem

Share this Article

Downloads: 130 | Monthly Hits: ⮙1

Review Papers, Medicine Science, India, Volume 8 Issue 9, September 2019

Pages: 629 - 633

A Review on Inflammatory Bowel Disease and their Treatment

Mojabir Hussen Ansari, Dr. Sheelpriya R. Walde

Share this Article

Similar Articles with Keyword 'dismutase'

Downloads: 101

Research Paper, Medicine Science, Iraq, Volume 4 Issue 11, November 2015

Pages: 2262 - 2264

Evaluate the Effect of Coenzymeq10 Supplementation on Reducing Oxidative Stress in Patients with Relapsing Remitting Multiple Sclerosis

Mariam Omran Waheed, Haider Al- Tukmagi, Ali Kadhim Kareem

Share this Article

Downloads: 130 | Monthly Hits: ⮙1

Review Papers, Medicine Science, India, Volume 8 Issue 9, September 2019

Pages: 629 - 633

A Review on Inflammatory Bowel Disease and their Treatment

Mojabir Hussen Ansari, Dr. Sheelpriya R. Walde

Share this Article

Similar Articles with Keyword 'Glutathione'

Downloads: 119

Research Paper, Medicine Science, India, Volume 5 Issue 7, July 2016

Pages: 1402 - 1405

Correlation between Plasma Protein Carbonyl Adducts and RBC Reduced Glutathione Level in Beta Thalassemia Major Patients in Southern Asian Region

Tanima Mandal, Santa Saha, Pradipta Ghosh, Suman Chatterjee, Pinaki Sarkar

Share this Article

Downloads: 130 | Monthly Hits: ⮙1

Review Papers, Medicine Science, India, Volume 8 Issue 9, September 2019

Pages: 629 - 633

A Review on Inflammatory Bowel Disease and their Treatment

Mojabir Hussen Ansari, Dr. Sheelpriya R. Walde

Share this Article

Similar Articles with Keyword 'peroxidase'

Downloads: 112

Research Paper, Medicine Science, Italy, Volume 3 Issue 10, October 2014

Pages: 1424 - 1427

Relationship between Serum 25-Hydroxyvitamin D and Thyroid Hormones during Pregnancy in the North of Rome

Gabriella Lavalle, Maria Elisabetta Onori

Share this Article

Downloads: 120

Case Studies, Medicine Science, India, Volume 6 Issue 1, January 2017

Pages: 1964 - 1966

An Unusual Cause for Altered Sensorium - A Case Report

Dr. S. Chandara Gandhimathi, Dr. R. B. Sudagar Singh, Dr. Preetam Arthur

Share this Article
Top