International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064


Downloads: 101

Research Paper | Biochemistry Science | Egypt | Volume 5 Issue 2, February 2016


Effect of L-carnitine on Lead-induced Infertility in Female Rats

Gamal Galal | Tarek Abou Zed | Khalid Kahilo | Mustafa Shukry


Abstract: The correlation between lead toxicity and infertility was confirmed in many studies. The present study aimed to explore the effect of L-carnitine on the adverse effects caused by lead metal on female rat fertility. Animals were organized into four groups (negative control group, lead acetate positive control group (50mg/L), L-carnitine low dose group (50mg/Kg Bwt/day) and L-carnitine high dose group (100mg/Kg Bwt/day). After 21 day period of treatment blood samples were collected and female rat ovaries were excised for Estradiol quantitative estimation and CYP19a1 gene expression respectively, samples were collected related to the four phases of the estrous cycle. The results of the present study revealed that lead metal in a dose of (50mg/L) causes significant decreases (p<0.05) of CYP19a1 gene expression and estradiol hormone level. L-carnitine have an outstanding beneficial effects on the previous two parameters which increased by increasing the dose. Therefore, the potential of using Lcarnitine to combat lead metal adverse effects on female infertility is very promising.


Keywords: Lead toxicity, female rat fertility, Estrous cycle, CYP19a1 gene, Estradiol, L-carnitine


Edition: Volume 5 Issue 2, February 2016,


Pages: 1492 - 1499


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How to Cite this Article?

Gamal Galal, Tarek Abou Zed, Khalid Kahilo, Mustafa Shukry, "Effect of L-carnitine on Lead-induced Infertility in Female Rats", International Journal of Science and Research (IJSR), Volume 5 Issue 2, February 2016, pp. 1492-1499, https://www.ijsr.net/get_abstract.php?paper_id=NOV161415

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