Cytokine Profile in JE and non JE Encephalitis
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064



Downloads: 124

Research Paper | Pediatrics | India | Volume 5 Issue 2, February 2016

Cytokine Profile in JE and non JE Encephalitis

Mahima Mittal, Mohammed Junaid Ansari, Shahla Abrar, Ashok K. Pandey

Background & Objectives Encephalitis is parenchymal brain inflammation due to infectious or immune-mediated processes. Acute Encephalitis Syndrome due to unidentified causes has been an issue of concern in eastern Uttar Pradesh. This study was undertaken to study the cytokine response in JE and non JE AES. Methodology This prospective study was performed in patients with acute encephalitis syndrome (AES) aged 1 to 15 years who had been admitted to a tertiary care teaching hospital. Patients who tested positive for typhoid, malaria, measles, mumps, herpes (HSV), Dengue were excluded. Serum and CSF samples of JE positive and non JE cases were further analysed for cytokine levels - Tumor necrosis factor -, Interferon-, Interleukin-10 and chemokines interferon activated protein-10 and RANTES. Results 12 were positive for JE IgM and 58 cases were from the Non JE category in which no aetiology was detected. Cytokines were tested in 45 patients, 12 were of JE and rest 33 of non JE. CSF level of IFN-, IL-10 and IP-10 were significantly higher in Non JE patients than in JE patients. IP-10 cut off levels in CSF of more than 1223.24 were helpful in differentiating non JE from JE with a sensitivity of 72.73 % and specificity of 66.63 %. Conclusion This study highlights the differences in immunological response of the JE and non JE cases. Interferon gamma inducible protein-10 (IP-10), a chemokine was siginificantly increased in the non JE group and turned out to be a fairly sensitive test in differentiating JE from non JE.

Keywords: AES, JE, non JE, cytokine, IP- 10

Edition: Volume 5 Issue 2, February 2016

Pages: 1112 - 1117

Share this Article

How to Cite this Article?

Mahima Mittal, Mohammed Junaid Ansari, Shahla Abrar, Ashok K. Pandey, "Cytokine Profile in JE and non JE Encephalitis", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=NOV161367, Volume 5 Issue 2, February 2016, 1112 - 1117

Enter Your Email Address




Similar Articles with Keyword 'AES'

Downloads: 40

Research Paper, Pediatrics, India, Volume 6 Issue 11, November 2017

Pages: 259 - 262

Anaesthetic Management of Neonate with Giant Occipital Meningoencephalocele: Case Report

Dr. Rajan Pandya; Dr. Suman Sahu; Dr. Olvyna D'Souza; Dr. Samrajni Ganguly

Share this Article

Downloads: 100

Research Paper, Pediatrics, India, Volume 4 Issue 4, April 2015

Pages: 1137 - 1141

Effectiveness of Oil Massage on Weight Gain and Selected Physiological Parameters among Preterm Babies in Selected Hospitals

K. Prasanna, Radhika M.

Share this Article

Similar Articles with Keyword 'JE'

Downloads: 1

Research Paper, Pediatrics, Indonesia, Volume 10 Issue 6, June 2021

Pages: 1056 - 1059

The Relationship between Social Quotient with Global Developmental Delay in Children

I Gusti Ayu Made Dwisri Okadharma Liran, I Gusti Ayu Trisna Windiani, I Gusti Agung Ngurah Sugitha Adnyana, Soetjiningsih

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Pediatrics, Indonesia, Volume 10 Issue 6, June 2021

Pages: 1629 - 1634

Mortality Patterns among Critically Ill Children in a Pediatric Intensive Care Unit of a Sanglah Hospital

Ni Made Dewi Aryati, I Nyoman Budi Hartawan, Dyah Kanya Wati, Ida Bagus Gede Suparyatha

Share this Article



Top