International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 111

Research Paper | Medicine Science | Indonesia | Volume 5 Issue 1, January 2016


High Antitumor Activity of Ethanolic Extracts of Papua's Ant Nest Plant (Myrmecodia tuberosa) on an Oral Carcinoma (KB) Cell Line

Sartari Entin Yuletnawati, Edi Meiyanto, Dewi Agustina


Abstract: Papuas ant nest (Myrmecodia tuberosa) is a traditional plant that is known to have the strong anticancer compound. Efficacy of ant nest was shown by the content of active substances include flavonoids, polyphenols, tannins and glycosides. Ant nest plant has been used to treat various diseases traditionally and safely without any side effects. Aims of the study were to examine the high antitumor activity of ethanolic extracts of Papuas ant nest plant on an oral carcinoma cells through the growth inhibition and apoptosis induction of KB cells. In the present study, KB cells were treated with various concentration of ethanol extract of Papuas ant nest plant. MTT assay was conducted to determine the growth inhibition of KB cells. The double-staining analysis was carried out to evaluate the induction of cells apoptosis. The results revealed the growth of KB cells treated with ant nest extract was remarkable suppressed. The percentage of cell inhibition was known at 84.2 %. Therefore, apoptosis of KB cells was markedly induced characterized by an increase in death cells. Percentage of apoptosis was detected at 88 %. In addition, the fifty-inhibitory concentration (IC50) of Papuas ant nest was reported at 215 g/ml in KB cell line. These results indicated that Papuas ant nest plant exhibited a high potential antitumor activity in oral carcinoma KB cells.


Keywords: Papuas ant nest plant, ethanolic extract, growth inhibition, apoptosis, KB cells


Edition: Volume 5 Issue 1, January 2016,


Pages: 1619 - 1623


How to Cite this Article?

Sartari Entin Yuletnawati, Edi Meiyanto, Dewi Agustina, "High Antitumor Activity of Ethanolic Extracts of Papua's Ant Nest Plant (Myrmecodia tuberosa) on an Oral Carcinoma (KB) Cell Line", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=NOV1531391, Volume 5 Issue 1, January 2016, 1619 - 1623

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'growth inhibition'

Downloads: 82

Research Paper, Medicine Science, Indonesia, Volume 4 Issue 12, December 2015

Pages: 1639 - 1644

Up-Regulation of S-Phase Kinase Associated Protein-2 Antisense Induces Cell Growth and Migration Chemotactic Suppression and Apoptosis in a Malignant Oral Burkitts Lymphoma Cells

Supriatno, Sartari Entin Yuletnawati

Share this Article

Downloads: 137

Research Paper, Medicine Science, Indonesia, Volume 5 Issue 1, January 2016

Pages: 429 - 434

Characteristics of New Primary Oral Cancer (Sp-C1) Cell and Antitumor Activity of Oligonucleotide p27Kip1 Sense on a Sp-C1 Cell

Supriatno, Sartari Entin Yuletnawati

Share this Article

Similar Articles with Keyword 'apoptosis'

Downloads: 82

Research Paper, Medicine Science, Indonesia, Volume 4 Issue 12, December 2015

Pages: 1639 - 1644

Up-Regulation of S-Phase Kinase Associated Protein-2 Antisense Induces Cell Growth and Migration Chemotactic Suppression and Apoptosis in a Malignant Oral Burkitts Lymphoma Cells

Supriatno, Sartari Entin Yuletnawati

Share this Article

Downloads: 105

Research Paper, Medicine Science, Egypt, https://www.ijsr.net/issue.php?edition=Volume%204%20Issue%202,%20February%20201

Pages: 1615 - 1619

Urinary Tumor Necrosis Factor-Like Weak Inducer of Apoptosis (TWEAK) As a Marker for Lupus Nephritis Activity

Mohamed Elsayed, Khaled A. Elhefnawy, Anas A. Qassem, Ghada E. Amr

Share this Article

Similar Articles with Keyword 'ant'

Downloads: 135 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Medicine Science, India, Volume 3 Issue 6, June 2014

Pages: 1591 - 1598

Increasing Prevalence of Chronic Obstructive Pulmonary Disease;Tuberculosis; Lung Cancer and Rising Environmental Oestrogen

Elizabeth JeyaVardhini Samuel, Nagarajan Natarajan

Share this Article

Downloads: 118

Research Paper, Medicine Science, United Kingdom, Volume 9 Issue 6, June 2020

Pages: 1893 - 1903

Examination of Cognitive Deficits Produced by Sub-Chronic Ketamine Exposure in Rats

Christopher Wood, Mohammed Shoib

Share this Article

Similar Articles with Keyword 'nest'

Downloads: 37

Research Paper, Medicine Science, Saudi Arabia, Volume 6 Issue 1, January 2017

Pages: 2450 - 2458

Awareness on Diabetes Complications and Protective Measures in Makkah Region among Known Diabetic Patients: A Cross-Sectional Survey

Anoud R. Omer; Abdullah A. Alghamdi; Rakan A. AlYamani; Salman H. Alqurash; Abdulaziz A. Alshikh; Roa'a A. Alshaik; Mohamed E. Salih; Anees A Sindi

Share this Article

Downloads: 101

Research Paper, Medicine Science, Sri Lanka, Volume 3 Issue 9, September 2014

Pages: 1495 - 1499

Staff Perceptions of Academic Integrity among Medical Students: A Study Conducted in a Higher Education Institute in Sri Lanka

D H Edussuriya, K N Marambe, P M N Wanniarachchi, R S Ramanayake

Share this Article

Similar Articles with Keyword 'plant'

Downloads: 135 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Medicine Science, India, Volume 3 Issue 6, June 2014

Pages: 1591 - 1598

Increasing Prevalence of Chronic Obstructive Pulmonary Disease;Tuberculosis; Lung Cancer and Rising Environmental Oestrogen

Elizabeth JeyaVardhini Samuel, Nagarajan Natarajan

Share this Article

Downloads: 93

Research Paper, Medicine Science, Albania, Volume 9 Issue 11, November 2020

Pages: 108 - 115

Correction of Simptomatic Flexible Flatfoot - A Review

Edvin Selmani, Vilson Ruci

Share this Article

Similar Articles with Keyword 'extract'

Downloads: 94

Research Paper, Medicine Science, Macedonia, Volume 4 Issue 9, September 2015

Pages: 1909 - 1913

The Localization of Dental Calcifications in Radicular Pulp

Pavlina Aleksova

Share this Article

Downloads: 95

Research Paper, Medicine Science, Macedonia, Volume 4 Issue 7, July 2015

Pages: 1965 - 1967

Analysis of Radicular Dental Calcifications According to the Shape

Pavlina Aleksova

Share this Article

Similar Articles with Keyword 'growth'

Downloads: 2

Research Paper, Medicine Science, Albania, Volume 4 Issue 3, March 2015

Pages: 2216 - 2218

Operative Treatment of Thyroid Nodules

Lulezim Lekaj, Ardian Dajti, Edmond eliku

Share this Article

Downloads: 82

Research Paper, Medicine Science, Indonesia, Volume 4 Issue 12, December 2015

Pages: 1639 - 1644

Up-Regulation of S-Phase Kinase Associated Protein-2 Antisense Induces Cell Growth and Migration Chemotactic Suppression and Apoptosis in a Malignant Oral Burkitts Lymphoma Cells

Supriatno, Sartari Entin Yuletnawati

Share this Article

Similar Articles with Keyword 'inhibition'

Downloads: 82

Research Paper, Medicine Science, Indonesia, Volume 4 Issue 12, December 2015

Pages: 1639 - 1644

Up-Regulation of S-Phase Kinase Associated Protein-2 Antisense Induces Cell Growth and Migration Chemotactic Suppression and Apoptosis in a Malignant Oral Burkitts Lymphoma Cells

Supriatno, Sartari Entin Yuletnawati

Share this Article

Downloads: 91

Research Paper, Medicine Science, Bulgaria, Volume 4 Issue 7, July 2015

Pages: 1169 - 1171

Contemporary Treatment of Parkinsons Disease

Mancheva-Ganeva Velina, Manchev Lachezar, Ganev Iordan, Manchev Ivan

Share this Article
Top