International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064




Downloads: 115

Research Paper | Microbiology | Kenya | Volume 5 Issue 1, January 2016


Antibiogram Profile of Extraintestinal Pathogenic Escherichia Coli Clinical Isolates From Patients with Urinary Tractinfections at Kericho District Hospital, Kenya

David Cheruiyot | Jackson Harold Odhiambo Onyuka | Olivia Wesula Lwande


Abstract: Background Escherichia coli is the common cause of primary urinary tract infections (UTIs). UTIs are the most common non-intestinal infection in women worldwide. Antimicrobial susceptibility testing provides information that allows physicians to select the 21 most appropriate antimicrobial agents for treating a specific infection. Methods A cross-sectional study was conducted at Kericho District Hospital in and out patients clinic between January and June 2015. A total of 133 urine samples were collected and used to investigate the prevalence of UTIs and to determine the antimicrobial profile of extraintestinal E. coli clinical isolates among in and out patients. UTIs were diagnosed using mid-stream urine culture on standard media. The bacterial isolates recovered were tested against trimethoprim-sulfamethoxazole, gentamycin, amikacin, ceftriaxone, ciprofloxacin, cefoxitin, cefepim, imipenem, ampicillin and amoxicillin-clavulanic acid using Kirby-Bauer disc diffusion technique. Data was entered in MS Excel spread sheet and analyzed by using SPSS version 20. Results Among the 133 samples examined, 38 % had E. coli isolates with 64 % of them being from female patients compared to 36 % from men. Approximately 73 % of the isolates were resistant to trimethoprim-sulfamethoxazole and 91 % resistant to amoxicillin clavulanic acid, 96 % were susceptible to imipenem and 82 % amikacine. E. coli showed high sensitivity to imipenem and amikacine but resistant to trimethoprin-sulfamethoxazole and amoxicillin-clavunic acid. Chi-square analysis indicated no association between gender of patient and pathogens isolate (p = 0.835).37 Escherichia coli was the most prevalent clinical isolate (p value = 0.905) although there was 38 no association between the age of patient and pathogens isolated in patients indicating a possibility of an equal chance of being infected irrespective of age. Escherichia coli was the most prevalent causative organism, showing multi drug resistance pattern. Conclusion Considering the relatively high rates of UTIs and drug resistance observed in this study, continued local, regional, and national surveillance is warranted. Imipenem and amikacine should be considered as drug of choice for empirical treatment of community acquired uncomplicated UTIs in patients in Kericho district hospital.


Keywords: Urinary tract infection, resistance, susceptible, antibiotic, bacteriuria


Edition: Volume 5 Issue 1, January 2016,


Pages: 1032 - 1038


How to Cite this Article?

David Cheruiyot, Jackson Harold Odhiambo Onyuka, Olivia Wesula Lwande, "Antibiogram Profile of Extraintestinal Pathogenic Escherichia Coli Clinical Isolates From Patients with Urinary Tractinfections at Kericho District Hospital, Kenya", International Journal of Science and Research (IJSR), Volume 5 Issue 1, January 2016, pp. 1032-1038, https://www.ijsr.net/get_abstract.php?paper_id=NOV152324

How to Share this Article?






Similar Articles with Keyword 'Urinary tract infection'

Downloads: 0

Research Paper, Microbiology, Nigeria, Volume 10 Issue 2, February 2021

Pages: 1026 - 1029

Prevalence of Urinary Tract Infection among Age Groups in Bauchi Metropolis, Nigeria

S. Isma'il

Share this Article

Downloads: 0

Research Paper, Microbiology, India, Volume 11 Issue 6, June 2022

Pages: 1739 - 1742

Study of Correlation between Antimicrobial Resistance and Biofilm Production among Uropathogenic Escherichia Coli Isolated from Patients Suspected of Urinary Tract Infection

Debabrata Barik | Ashisa Kumar Das | Dibya Prasana Mohanty | Susmita Kumari Sahu [2]

Share this Article


Top