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Comparative Studies | Anaesthesiology | India | Volume 11 Issue 1, January 2022

A Study for Evaluating Different Doses of Dexmedetomidine in Attenuating Extubation Response in Smoker Patients for Surgeries under General Anaesthesia

Vivek Chaudhary ^[3]

Abstract: Introduction: Smokers are one of the at-risk group of patients prone for developing complications during extubation. Objective: A study for evaluating different doses of dexmedetomidine in attenuating extubation response in smoker patients for surgeries under general anaesthesia. Study design: Prospective randomized study. Method: The present study was carried out and completed on ninety ASA II patients, aged between 40-60 years posted for surgery under general anaesthesia. Total 90 patients who fulfilled our inclusion and exclusion criteria were included in the study and divided randomly into three groups: Group A(n=30) 0.5?g/kg of dexmedetomidine in NS (Total volume 10 ml) Group B(n=30) 0.75?g/kg of dexmedetomidine in NS (Total volume 10 ml) Group C(n=30) 1?g/kg of dexmedetomidine in NS (Total volume 10 ml). Results: The difference in quality of extubation was significant between group A and group B and between group A and group C whereas it was comparable between group B and group C. Suggesting that extubation was better in group B and group C with dexmedetomidine dose 0.75 ?g/kg and 1 ?g/kg respectively. None of the patients had post-operative complications such as laryngospasm, bronchospasm, or severe coughing. None of the patient had respiratory depression. None of the patients had hypotension (MAP < 65 mmHg or more than 20% decrease in SBP from baseline value or SBP<80 mm of Hg). Conclusion: We conclude that dexmedetomidine with dose of 0.75 ?g/kg is the best dose for attenuation of extubation response in current smoker patients undergoing major surgery.

Keywords: Surgery, dexmedetomidine, extubation

Edition: Volume 11 Issue 1, January 2022,

Pages: 1096 - 1099

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