International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 10

Research Paper | Anaesthesiology | India | Volume 10 Issue 4, April 2021


Comparison of Nalbuphine / Fentanyl as Opioid Adjuvant to Propofol based TIVA for Laser Surgery of Larynx

Dr. Rupal J. Shah, Dr. Manisha Kapdi, Dr. Vishal Prajapati, Dr Yatri Joshi


Abstract: Background: Laser surgeries of larynx are very much common. There are chances of combustion during laser application. To prevent it TIVA with propofol is very much important. Aims & Objective: To compare Nalbuphine and fentanyl as analgesic adjuvant, in total intravenous anaesthesia with propofol infusion in laser surgery of larynx. Study design: Double blind randomised. Methods: Changes in haemodynamic variables greater than twenty percent above or below the baseline and recovery profile were observed. Results: Blood pressure remained within 20% of baseline in either group. Nine patients in fentanyl and fifteen in nalbuphine group required an additional bolus of propofol intraoperatively. Heart rate response after tracheal intubation was significantly higher in the nalbuphine group (25%). No difference was observed in the incidence of nausea and vomiting in the recovery room. Twenty-seven percent patients in the nalbuphine group required analgesia in the recovery in comparison to 87% in the fentanyl group. Patients in the fentanyl group required analgesia earlier (37 minutes vs.62 minutes). Conclusion: Fentanyl provided better intraoperative haemodynamic stability in comparison to nalbuphine when used as the analgesic component in total intravenous anaesthesia with propofol. The recovery profile with both drugs was similar. Lesser number of patients required analgesia in the recovery in the nalbuphine group.


Keywords: Nalbuphine, Fentanyl, Propofol, Laser surgery of larynx


Edition: Volume 10 Issue 4, April 2021,


Pages: 741 - 746


How to Cite this Article?

Dr. Rupal J. Shah, Dr. Manisha Kapdi, Dr. Vishal Prajapati, Dr Yatri Joshi, "Comparison of Nalbuphine / Fentanyl as Opioid Adjuvant to Propofol based TIVA for Laser Surgery of Larynx", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=MR21414174246, Volume 10 Issue 4, April 2021, 741 - 746

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Fentanyl'

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima, Dr M. H. Nagrale

Share this Article

Downloads: 23

Research Paper, Anaesthesiology, Egypt, Volume 10 Issue 3, March 2021

Pages: 1567 - 1572

Low Dose Combined Spinal-Epidural Anesthesia Versus Conventional Epidural Anesthesia for Elective Cesarean Section in Severe Preeclampsia

Mamdouh E. Lotffy, Ayman A. Radi, Dr. Nevine M. Soliman, Dr. Khaled M. Gaballah, Amir R. Youssef

Share this Article

Similar Articles with Keyword 'Propofol'

Downloads: 62

Research Paper, Anaesthesiology, India, Volume 9 Issue 12, December 2020

Pages: 1158 - 1167

Pharmacologic Neuroprotection

Dr V Giri Prasath, Dr Chandrasekhar Krishnamurti

Share this Article

Downloads: 100

Research Paper, Anaesthesiology, India, Volume 9 Issue 2, February 2020

Pages: 1017 - 1019

Comparison of Haemodynamic Response to Tracheal Intubation Using Propofol versus Etomidate

Dr. Rekha Meena, Dr. Narendra Singh Choudhary

Share this Article
Top