International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




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Masters Thesis | Biomedical Sciences | Indonesia | Volume 10 Issue 4, April 2021


Comparison between Oral Ethanol Vegetable Fern Leaves (Diplazium esculentum) Extract and Simvastatin to Improve Lipid Profile and Decrease F2-isoprostane Level in Wistar Male Rats (Rattus norvegicus) With Dyslipidemia

Marlene Irawan, Anak Agung Gde Budhiarta, Ida Sri Iswari


Abstract: Background: In dyslipidemia, lipid profile and lipid peroxidation increases. Lipid peroxidation was measured by F2-isoprostane level. Vegetable fern contains flavonoid and other constituent. This research aims to prove administration of oral ethanol vegetable fern leaves extract improves lipid profile and decrease F2-isoprostane level in male Wistar rats compared to simvastatin. Methods: This study used experimental pre test ? post test control group design, 14 wistar rats, males, 2, 5-3 months old, weighing 140-200 grams, divided into 2 groups. Simvastatin group was given simvastatin 0, 36 mg, whereas vegetable fern groupwas given oral ethanol vegetable fern leaves extract 100 mg, by intragastric force-feeding, once a day, for 21 days. Blood serum has been used to measure lipid profile and F2-isoprostane level. Results: There was a decrease in total cholesterol level after intervention, not only in simvastatin group (221.45 mg/dL vs 191.61 mg/dL; p=0.001) but also vegetable fern group (225.24 mg/dL vs 196.54 mg/dL; p=0.002). LDLalso decreased in both groups (135.67 mg/dL vs 86.69 mg/dL; p<0.001 and 140.56 mg/dL vs 98.86 mg/dL; p<0.001). HDL increased in both groups (52.69 mg/dL vs 77.20 mg/dL; p<0.001 and 51.73 mg/dL vs 68.95 mg/dL; p<0.001). Triglyceride level decreased in both groups (165.40 mg/dL vs 138.58 mg/dL; p=0.002and164.78 mg/dL vs 143.66 mg/dL; p=0.003). F2-isoprostane level decreased in simvastatin group not significantly (11.87 ng/L vs 11.27 ng/L; p=0.420), but decreased significantly in vegetable fern group (12.18 ng/L vs 4.05 ng/L; p<0.001). Comparison between two groups after intervention showed no significant differences regarding delta total cholesterol, delta LDL, and delta triglyceride (p>0.05). Conclusion: As conclusion, administration of oral ethanol vegetable fern leaves extract improved lipid profile level in wistar male rats with dyslipidemianot as good as simvastatin but decreased F2-isoprostane better than simvastatin.


Keywords: Dyslipidemia, Vegetable fern leaves, Lipid profile, F2-isoprostane


Edition: Volume 10 Issue 4, April 2021,


Pages: 615 - 619


How to Cite this Article?

Marlene Irawan, Anak Agung Gde Budhiarta, Ida Sri Iswari, "Comparison between Oral Ethanol Vegetable Fern Leaves (Diplazium esculentum) Extract and Simvastatin to Improve Lipid Profile and Decrease F2-isoprostane Level in Wistar Male Rats (Rattus norvegicus) With Dyslipidemia", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=MR21412135858, Volume 10 Issue 4, April 2021, 615 - 619

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