International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Reviewed

ISSN: 2319-7064


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Research Paper | Pharmaceutical Science | India | Volume 10 Issue 11, November 2021


Simultaneous Estimation of Atorvastatin and Fenofibrate by HPTLC in Pharmaceutical Mixture

N. Santhi [2] | S. S. Rajendran | Akshaya Karthigeyan


Abstract: The paper present the development and validation of an improved method for the simultaneous analysis of Atorvastatin (ATO) and Fenofibrate (FEN) as the bulk drug and in tablet dosage forms using high - performance thin - layer chromatography (HPTLC) with densitometric detection. Separation was performed on silica gel 60 F 254 plates. The mobile phase is composed of Toluene: chloroform: methanol: glacial acetic acid (4.6: 3: 1.4: 0.1). Densitometric evaluation of the separated zones was performed at 254 nm. The drugs were satisfactorily resolved with RF values of 0.25?0.03 and 0.89?0.03 for ATO and FEN, respectively. The accuracy and reliability of the method was assessed by evaluation of linearity 200 - 1000 ng per spot for ATO and 200 - 1000 ng per spot for FEN), precision intra - day and inter - day RSD values were always less than 1.51 for the titled drugs, accuracy (96.4% ?5% for ATO and 100.2% ?5% for FEN) and specificity, based on ICH guidelines.


Keywords: Atorvastain, Fenofibrate, HPTLC


Edition: Volume 10 Issue 11, November 2021,


Pages: 1215 - 1219


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How to Cite this Article?

N. Santhi, S. S. Rajendran, Akshaya Karthigeyan, "Simultaneous Estimation of Atorvastatin and Fenofibrate by HPTLC in Pharmaceutical Mixture", International Journal of Science and Research (IJSR), Volume 10 Issue 11, November 2021, pp. 1215-1219, https://www.ijsr.net/get_abstract.php?paper_id=MR211123105115

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