Downloads: 1
Research Paper | Pharmaceutical Science | India | Volume 10 Issue 11, November 2021
Simultaneous Estimation of Atorvastatin and Fenofibrate by HPTLC in Pharmaceutical Mixture
N. Santhi [2] | S. S. Rajendran | Akshaya Karthigeyan
Abstract: The paper present the development and validation of an improved method for the simultaneous analysis of Atorvastatin (ATO) and Fenofibrate (FEN) as the bulk drug and in tablet dosage forms using high - performance thin - layer chromatography (HPTLC) with densitometric detection. Separation was performed on silica gel 60 F 254 plates. The mobile phase is composed of Toluene: chloroform: methanol: glacial acetic acid (4.6: 3: 1.4: 0.1). Densitometric evaluation of the separated zones was performed at 254 nm. The drugs were satisfactorily resolved with RF values of 0.25?0.03 and 0.89?0.03 for ATO and FEN, respectively. The accuracy and reliability of the method was assessed by evaluation of linearity 200 - 1000 ng per spot for ATO and 200 - 1000 ng per spot for FEN), precision intra - day and inter - day RSD values were always less than 1.51 for the titled drugs, accuracy (96.4% ?5% for ATO and 100.2% ?5% for FEN) and specificity, based on ICH guidelines.
Keywords: Atorvastain, Fenofibrate, HPTLC
Edition: Volume 10 Issue 11, November 2021,
Pages: 1215 - 1219
Similar Articles with Keyword 'HPTLC'
Downloads: 0
Research Paper, Pharmaceutical Science, India, Volume 11 Issue 11, November 2022
Pages: 302 - 305Novel HPTLC Method for Estimation of Fluocinonide
Pooja Kumari Jaiswal | Dr Vandana Jain
Downloads: 193
Research Paper, Pharmaceutical Science, India, Volume 9 Issue 3, March 2020
Pages: 246 - 251Comparative Qualitative and Quantitative Phytochemical Evaluation of Embelia ribes Burm F Obtained from Different Sources
Syed Asadulla | Salma Khanam | Zeeshan Afsar