Research Paper | Hematology | Iraq | Volume 8 Issue 8, August 2019
The Value of Immunohistochemistry of P53 and Ki67 in Non-Hodgkin's Lymphoma
Dr. Harith Sami Ali | Dr. Israa Saadi Abbas | Dr. Ahmed Jassim Hammadee
Abstract: Aims-To determine the frequency of P53 & Ki67 proteins, as detected by immunohistochemistry in lymph node biopsies of Iraqi NHL patients, to investigate their pattern of expression and to study the correlations and comparisons between P53 and Ki67 immunohistochemical detections and various clinical and histological parameters of NHL patients in order to specify their importance as prognostic factors in NHL patients. A total of 85 non-Hodgkin's lymphoma Iraqi patients including 54 males and 31 females cases, who has lymph nodes biopsies. Using the Working Formulation classification, the most common grade encountered was the Intermediate grade NHL constituted (65.9%) of the cases, while the lowest commoner was the Low grade with frequency of (15.3%). High grade lymphoma was encountered in (18.8%). The overall frequency of both P53 and Ki67 proteins positivity in NHL cases included was (63.5%) and (68.2%) respectively. Regarding the P53 and Ki67 results, no significant difference were found concerning age, sex, site of lymph node biopsy, and sclerosis which present in some morphological subtype of NHL. However there were statistically significant differences between P53 or Ki67 and different histological grade of NHL, whereby both P53 positivity and Ki67 expression were found to increase significantly (P
Keywords: Non-Hodgkin's lymphoma, immunohistochemistry, P53, Ki67
Edition: Volume 8 Issue 8, August 2019,
Pages: 1543 - 1553
How to Cite this Article?
Dr. Harith Sami Ali, Dr. Israa Saadi Abbas, Dr. Ahmed Jassim Hammadee, "The Value of Immunohistochemistry of P53 and Ki67 in Non-Hodgkin's Lymphoma", International Journal of Science and Research (IJSR), Volume 8 Issue 8, August 2019, pp. 1543-1553, https://www.ijsr.net/get_abstract.php?paper_id=ART2020518
How to Share this Article?
Similar Articles with Keyword 'lymphoma'
Familial Hemophagocytic Syndrome in A Neonate??- A Rare Case Report
The Association between Comorbidity and Survivorship among non-Hodgkin lymphoma Patients in Albania
Adriana Hatellari | Arben Ivanaj  | Ervin Toci