International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 187

Research Paper | Biological Sciences | Philippines | Volume 9 Issue 2, February 2020


Antihyperglycemic Activity of the Crude Ethanolic Extract of Artocarpus heterophyllus Lam. (langka) Unripe Fruit against Alloxan-induced Hyperglycemia in Mus musculus (White Mice)

Ma. Socorro G. Leong-on


Abstract: This study was conducted to determine the anti-hyperglycemic activity of the crude ethanolic extract ofArtocarpus heterophyllus Lam. (langka) unripe fruit using the method alloxan induced hyperglycemia in Mus musculus white mice. The different extract concentrations of A. heterophyllus were orally administered to the fasted hyperglycemic white mice. On the first, second and third hour after extract administration, fasting blood sugar (FBS) was measured and percent reduction in FBS were compared. The study showed that the crude ethanolic extract of A. heterophyllus unripe fruit exhibited anti-hyperglycemic activity at 5mg/20g (250mg/kg), 10mg/20g (500mg/kg), 15mg/20g (750mg/kg) on the third hour after the extract administration. Their results differ significantly to the negative control - dist. water (7.27+0.52) (P0.05). On the first and second hour, both 10mg and 15mg/20g bw of white mice exhibited anti-hyperglycemic activity but were not comparable to the positive control. The antihyperglycemic activity were concentration and time dependent. The best concentration that exhibited anti-hyperglycemic activity was at 15mg/20g bw of white mice and best time was on the third hour. The study demonstrated the anti-hyperglycemic activity of the crude ethanolic extract of A. heterophyllus unripe fruit at 5mg/20g, 10mg/20g, 15mg/20g against alloxan-induced diabetes in white mice. This study could serve as basis for future formulation of effective, low cost and locally available antihyperglycemic agent from A. heterophyllus unripe fruit subject for further study.


Keywords: anti-hyperglycemic activity, Artocarpus heterophyllus, alloxan-induced hyperglycemia, crude ethanolic extract


Edition: Volume 9 Issue 2, February 2020,


Pages: 144 - 148


How to Cite this Article?

Ma. Socorro G. Leong-on, "Antihyperglycemic Activity of the Crude Ethanolic Extract of Artocarpus heterophyllus Lam. (langka) Unripe Fruit against Alloxan-induced Hyperglycemia in Mus musculus (White Mice)", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=ART20204618, Volume 9 Issue 2, February 2020, 144 - 148

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'activity'

Downloads: 172 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Biological Sciences, India, Volume 7 Issue 5, May 2018

Pages: 122 - 125

Preliminary Phytochemical Screening and Antimicrobial Activity of Cotyledon of Two Variety of Mangifera indica L.

U. Arul Pamila, S. Karpagam

Share this Article

Downloads: 40

Research Paper, Biological Sciences, Congo, Volume 10 Issue 1, January 2021

Pages: 1364 - 1368

Assessment of Anxiolytic and Antidepressant Effects of Crossopteryxfebrifuga in Mice

D J Bassoueka, B E A Loufoua, A A Abena

Share this Article

Similar Articles with Keyword 'crude'

Downloads: 123

Research Paper, Biological Sciences, India, Volume 6 Issue 4, April 2017

Pages: 998 - 1000

Preliminary Phytochemical Screening of Seeds and Leaves of Hydnocarpus Wightiana Blume

Naziya Habeeb M.

Share this Article

Downloads: 124

Research Paper, Biological Sciences, Nigeria, Volume 7 Issue 12, December 2018

Pages: 1364 - 1368

Effects of Crude Oil on Fresh and Dry Weights of solanum melongena, Phaseolus vulgaris and Cucumis sativus Amended with Leaf Litter and Hydrogen Peroxide

Chuku O.S., Ekweozor I.K.E., Jaja E.T.

Share this Article

Similar Articles with Keyword 'ethanolic'

Downloads: 123

Research Paper, Biological Sciences, India, Volume 6 Issue 4, April 2017

Pages: 998 - 1000

Preliminary Phytochemical Screening of Seeds and Leaves of Hydnocarpus Wightiana Blume

Naziya Habeeb M.

Share this Article

Downloads: 133 | Monthly Hits: ⮙1

Research Paper, Biological Sciences, Saudi Arabia, Volume 6 Issue 11, November 2017

Pages: 1391 - 1394

Phytochemical Screening and Antioxidant Activity Evaluation of Papaver Somniferum L Seed Extract from Eastern Sudan

Khadiga G. Abd Elaleem, Badr Eldin A.E. Saeed, Hajer Alsiyed Ahamed

Share this Article

Similar Articles with Keyword 'extract'

Downloads: 172 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Biological Sciences, India, Volume 7 Issue 5, May 2018

Pages: 122 - 125

Preliminary Phytochemical Screening and Antimicrobial Activity of Cotyledon of Two Variety of Mangifera indica L.

U. Arul Pamila, S. Karpagam

Share this Article

Downloads: 112

Research Paper, Biological Sciences, Indonesia, Volume 9 Issue 7, July 2020

Pages: 1180 - 1184

The Combination Effect Analysis of Catharanthus roseus, Abelmoschus manihot and Dysphania ambrosioides on Rattus norvegicus Blood Triglyceride Content

Bella Rebecca, Dingse Pandiangan, Agustina M. Tangapo

Share this Article
Top