International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064

Downloads: 238 | Monthly Hits: ⮙2

Review Papers | Cancer Science | India | Volume 9 Issue 1, January 2020

Warburg Effect and its Role in Cancer Cell Metabolism: A Review

Aastha Sharma

Abstract: Elevated glycolysis and impaired oxidative phosphorylation (Warburg effect) is one of the classical features of cancer. Cancer cells, in order to support their growth and proliferation needs both high energy and more biosynthetic intermediates, therefore they alter their metabolic activities. However, high proliferation rate of tumor cells often generates regions that become oxygen deficient. Therefore, their carbohydrate metabolism depends mostly on a glycolytic process that is coupled with oxidative phosphorylation. This metabolic switch, also known as the Warburg Effect, constitutes a fundamental adaptation of the tumor cells to a relatively hostile environment, and supports the evolution of aggressive and metastatic phenotypes. The glycolyic phenotype created due to Warburg Effect grants the cancer cells, in hypoxic conditions; a growth advantage by inducing various pro-proliferative and pro-invasive process like angiogenesis. This, tumor glycolysis may constitute an attractive target for cancer therapy. In this review, we discuss some of the mechanisms by which cancer cell metabolism may shape and modify the tumor microenvironment. Also, we will detail how two specific environmental factors present in the tumor microenvironment including hypoxia and acidosis, reciprocally affect cancer cell metabolism.

Keywords: Tumor microenvironment, Glutaminolysis, Chronic acidosis, Tumor hypoxia

Edition: Volume 9 Issue 1, January 2020,

Pages: 164 - 168

How to Cite this Article?

Aastha Sharma, "Warburg Effect and its Role in Cancer Cell Metabolism: A Review", International Journal of Science and Research (IJSR),, Volume 9 Issue 1, January 2020, 164 - 168

How to Share this Article?

Enter Your Email Address

Similar Articles with Keyword 'Tumor'

Downloads: 2

Research Paper, Cancer Science, Bangladesh, Volume 10 Issue 11, November 2021

Pages: 1068 - 1071

Comparative Study of Single Fraction and Multiple Fraction Palliative Radio Therapy for the Treatment of Bone Metastasis in Multiple Center of Bangladesh

Bhuiyan MZR, Rahman A, Rassell Md

Share this Article

Downloads: 5

Informative Article, Cancer Science, India, Volume 10 Issue 7, July 2021

Pages: 185 - 188

An Overview on the 10 Cellular Hallmarks of Cancer

Christina Rose George, Gimaya Gilbert, Samuel B Mathew, Blesson Varghese

Share this Article