Research Paper | Medicine Science | Congo | Volume 8 Issue 12, December 2019
Effect of Probiotic Yogurt Supplementation on Intestinal Inflammation and Oxidative Stress in HIV-Positive Patients on Antiretroviral Therapy: Randomized Controlled Trials in 24 and 48 Weeks
Kasamba Ilunga Eric, Balaka Ekwalanga Michel, Mulumba Kadiebwe David, Kalumba Kambote Athy, Ilunga Nikulu Julian, Lungu Anzwal, Kalenga Mwenze Kayamba Prosper, Malangu Mposhy Emmanuel Prosper
Human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) have been associated with high oxidative stress in HIV patients. The disparity in antioxidant levels and secondary inflammation due to intestinal bacterial translocation in people living with HIV is the leading cause of morbidity and mortality associated with HIV infection. Using a simple 1: 1 randomization, Efavirens (EFV) and Lopinavir (LPV) -treated antiretroviral (ARV) -treated patients were additionally supplemented with probiotic yogurt and then followed for 48 weeks and evaluated at inclusion, at mid- and at the end of the course, by the determination of markers: immunological (CD4), virological (viral load), inflammatory (soluble Hs CRP, CD14 and CD163) and oxidative stress [Superoxide dismuthase (SOD, glutathione peroxidase (GPx ) and Zinc]. The results confirm that HIV infection induces inflammation by a very significant increase in sCD14, sCD163 and HsCRP; and a collapse of the antioxidant protective system characterized by decreased levels of SOD, GPx, and Zinc. At weeks 24 and 48, a significant reversal of markers of inflammation and oxidative stress was observed under the ART + Probiotic Yogurt arm. Only the value of Zinc remained at a subnormal rate. All patients in the same arm had their undetected viral load since week 24. Although probiotic yogurt supplementation with ART has a significant impact on immunologic, virologic, inflammatory and oxidative stress markers compared to ARV only, it should be associated with Zinc for an optimal evolution of seropositive patients.
Keywords: HIV, Inflammation, Oxidative Stress Probiotic
Edition: Volume 8 Issue 12, December 2019
Pages: 365 - 373
How to Cite this Article?
Kasamba Ilunga Eric, Balaka Ekwalanga Michel, Mulumba Kadiebwe David, Kalumba Kambote Athy, Ilunga Nikulu Julian, Lungu Anzwal, Kalenga Mwenze Kayamba Prosper, Malangu Mposhy Emmanuel Prosper, "Effect of Probiotic Yogurt Supplementation on Intestinal Inflammation and Oxidative Stress in HIV-Positive Patients on Antiretroviral Therapy: Randomized Controlled Trials in 24 and 48 Weeks", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20203224, Volume 8 Issue 12, December 2019, 365 - 373
440 PDF Views | 159 PDF Downloads
Similar Articles with Keyword 'HIV'
M.Tech / M.E / PhD Thesis, Medicine Science, India, Volume 6 Issue 8, August 2017
Pages: 618 - 622Alcohol and Tobacco Use among the HIV/TB Co-Infected Individuals: A Case of Nepal
Bhim Bahadur Subba 'Phudong'; Dr. Nirmal Rimal
Research Proposals or Synopsis, Medicine Science, Saudi Arabia, Volume 5 Issue 12, December 2016
Pages: 2052 - 2056Review of the Level of Awareness Towards Occupational Injury among Restorative Staff at Selected Dental Clinics, Saudi Arabia
Dr. Duaa Adil Sharaf Sharaf
Informative Article, Medicine Science, India, Volume 7 Issue 2, February 2018
Pages: 1294 - 1296Hyperthyroidism - Presenting as Cachexia in Young Adult
Dr. Siraj S Vadhvaniya, Dr. Pramod R Jha, Dr. Raajan Kantharia
Research Paper, Medicine Science, Albania, Volume 3 Issue 10, October 2014
Pages: 1148 - 1151Frequency of HIV-AIDS Cases in the City of Vlora, in the Period September 2012 To 2013
Glodiana Sinanaj, Prof. Asoc Arjan Harxhi, Prof. Eduard Kakariqi
Research Paper, Medicine Science, South Africa, Volume 4 Issue 5, May 2015
Pages: 1488 - 1492Assessment of Knowledge and Attitude on Male Circumcision towards Reduction of HIV/AIDS among Residents of Ishaka Town Council-Uganda
Domnic Marera, Mercy Singoei, Cyprian Nyaribo
Similar Articles with Keyword 'Inflammation'
Research Paper, Medicine Science, Albania, Volume 4 Issue 12, December 2015
Pages: 988 - 990Acute Acalculous Cholecystitis Complicating the Course of Infectious Mononucleosis
Elda Skenderi MD, Gjeorgjina Kuli-Lito
Comparative Studies, Medicine Science, Bulgaria, Volume 4 Issue 1, January 2015
Pages: 1753 - 1757A Comparison of Three Different Radiographic Techniques to Evaluate Their Reproducibility Concerning Periapical Structures ? An Experimental Pilot Study
Gusiyska A, Kishkilova D
Research Paper, Medicine Science, India, Volume 3 Issue 8, August 2014
Pages: 2055 - 2059Inflammatory Infiltrate in the Respiratory Tract and Their Relationship to Respiratory Function Among Asthmatics in Accra, Ghana
Cecilia Smith, Audery Forson, Yao Tettey, Richard Gyasi
Research Paper, Medicine Science, Bulgaria, Volume 4 Issue 1, January 2015
Pages: 2428 - 2430Endometriosis and Serum Hepcidin Levels
Manolov V, Marinov B, Vasilev V, Tzatchev K, Hadjiev E, Bogov I, Hadjidekova S, Genchev G, Emilova R
Research Paper, Medicine Science, India, Volume 7 Issue 7, July 2018
Pages: 1318 - 1342Comparative Study of Imaging of Sacroiliitis by CT and MRI-Scan with Power Doppler Ultrasound in Spondyloarthritis
Samikrishnan P, Panchapakesa Rajendran C, Porkodi R