International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

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Research Paper | Hematology | India | Volume 8 Issue 11, November 2019

Prolific Drug Discovery Human ?-Hemoglobiopathies ? Thalassemia - Sickle Cell Anemia - Anemic Condition

Dr. Mukesh H. Shukla

Abstract: The Thalassemia are the commonest monogenic disorders in the world, and globally it is estimated that there are 270 million carriers, of which 80 million are carriers of -Thalassemia. -Thalassemia is widespread in the Mediterranean, Southeast Asian, African, and Middle East populations. The mean prevalence of this disease in India is 3.3 %. It has become much more common recently in northern and central Europe, including Germany, due to immigration. The Thalassemia refer to a diverse group of hemoglobin disorders characterized by a reduced synthesis of one or more of the globin chains (, , , , , , and). -thalassemia occurs when there is a deficiency of -globin, which is typically caused by a direct down-regulation in the synthesis of structurally normal b chains. However, a thalassemia phenotype can also arise from structural b chain variants if they are synthesized at a reduced rate. The most severe form of Thalassemia is characterized by the complete absence of HbA (22) which results from the inheritance of two homozygous -thalassemia alleles. This normally presents as a life-threatening anemia requiring blood transfusions from infancy. Inheritance of single -thalassemia alleles is presented by a clinically asymptomatic condition, but may show a mild anemia.

Keywords: Hemoglobin, Sickle Cell, Anemia, Bioactive, Chemistry, Beta Thallasemia

Edition: Volume 8 Issue 11, November 2019,

Pages: 1344 - 1347

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How to Cite this Article?

Dr. Mukesh H. Shukla, "Prolific Drug Discovery Human ?-Hemoglobiopathies ? Thalassemia - Sickle Cell Anemia - Anemic Condition", International Journal of Science and Research (IJSR), Volume 8 Issue 11, November 2019, pp. 1344-1347,

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